| Title: |
Association of Concentric Left Ventricular Hypertrophy With Subsequent Change in Left Ventricular End-Diastolic Volume ; The Dallas Heart Study |
| Authors: |
Garg, Sonia; de Lemos, James A.; Matulevicius, Susan A.; Ayers, Colby; Pandey, Ambarish; Neeland, Ian J.; Berry, Jarett D.; McColl, Roderick; Maroules, Christopher; Peshock, Ronald M.; Drazner, Mark H. |
| Source: |
Circulation: Heart Failure ; volume 10, issue 8 ; ISSN 1941-3289 1941-3297 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2017 |
| Description: |
Background In the conventional paradigm of the progression of left ventricular hypertrophy, a thick-walled left ventricle (LV) ultimately transitions to a dilated cardiomyopathy. There are scant data in humans demonstrating whether this transition occurs commonly without an interval myocardial infarction. Methods and Results Participants (n=1282) from the Dallas Heart Study underwent serial cardiac magnetic resonance ≈7 years apart. Those with interval cardiovascular events and a dilated LV (increased LV end-diastolic volume [EDV] indexed to body surface area) at baseline were excluded. Multivariable linear regression models tested the association of concentric hypertrophy (increased LV mass and LV mass/volume 0.67 ) with change in LVEDV. The study cohort had a median age of 44 years, 57% women, 43% black, and 11% (n=142) baseline concentric hypertrophy. The change in LVEDV in those with versus without concentric hypertrophy was 1 mL (−9 to 12) versus −2 mL (−11 to 7), respectively, P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/circheartfailure.117.003959 |
| DOI: |
10.1161/CIRCHEARTFAILURE.117.003959 |
| Availability: |
https://doi.org/10.1161/circheartfailure.117.003959; https://www.ahajournals.org/doi/full/10.1161/CIRCHEARTFAILURE.117.003959 |
| Accession Number: |
edsbas.F0B3BC7C |
| Database: |
BASE |