| Title: |
TZAP Mutation Leads to Poor Prognosis of Patients with Breast Cancer † |
| Authors: |
Yu-Ran Heo; Moo-Hyun Lee; Sun-Young Kwon; Jihyoung Cho; Jae-Ho Lee |
| Source: |
Medicina, Vol 55, Iss 11, p 748 (2019) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2019 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
tzap; telomere; breast carcinoma; zbtb48; Medicine (General); R5-920 |
| Description: |
Background and Objectives: ZBTB48 is a telomere-associated factor that has been renamed as telomeric zinc finger-associated protein (TZAP). It binds preferentially to long telomeres, competing with telomeric repeat factors 1 and 2. Materials and Methods: We analyzed the TZAP mutation in 128 breast carcinomas (BCs). In addition, its association with telomere length was investigated. Results: The TZAP mutation (c.1272 G > A, L424L) was found in 7.8% (10/128) of the BCs and was associated with the N0 stage. BCs with the TZAP mutation had longer telomeres than those without this mutation. Survival analysis showed that the TZAP mutation resulted in poorer overall survival. Conclusions : These results suggest that the TZAP mutation is a possible prognostic marker in BC. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/1010-660X/55/11/748; https://doaj.org/toc/1010-660X; https://doaj.org/article/3649c71f3fde480cabac661c606a7daf |
| DOI: |
10.3390/medicina55110748 |
| Availability: |
https://doi.org/10.3390/medicina55110748; https://doaj.org/article/3649c71f3fde480cabac661c606a7daf |
| Accession Number: |
edsbas.F112E09B |
| Database: |
BASE |