| Title: |
Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam |
| Authors: |
Phan, VTM; Rabaa, MA; Donato, C; Cowley, D; Voong, VP; Iran, TND; Pham, HA; Ha, V; Bryant, JE; Kellam, P; Thwaites, G; Woolhouse, MEJ; Kirkwood, CD; Baker, S |
| Publisher Information: |
MICROBIOLOGY SOC |
| Publication Year: |
2014 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
During a hospital-based diarrhoeal disease study conducted in Ho Chi Minh City, Vietnam from 2009 to 2010, we identified four symptomatic children infected with G26P[19] rotavirus (RV)--an atypical variant that has not previously been reported in human gastroenteritis. To determine the genetic structure and investigate the origin of this G26P[19] strain, the whole genome of a representative example was characterized, revealing a novel genome constellation: G26-P[19]-I5-R1-C1-M1-A8-N1-T1-E1-H1. The genome segments were most closely related to porcine (VP7, VP4, VP6 and NSP1) and Wa-like porcine RVs (VP1-3 and NSP2-5). We proposed that this G26P[19] strain was the product of zoonotic transmission coupled with one or more reassortment events occurring in human and/or animal reservoirs. The identification of such strains has potential implications for vaccine efficacy in south-east Asia, and outlines the utility of whole-genome sequencing for studying RV diversity and zoonotic potential during disease surveillance. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0022-1317 |
| Relation: |
https://hdl.handle.net/11343/261223 |
| Availability: |
https://hdl.handle.net/11343/261223 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.F12772DA |
| Database: |
BASE |