| Title: |
Effect of Cytomegalovirus-Induced Immune Response, Self Antigen-Induced Immune Response, and Microbial Translocation on Chronic Immune Activation in Successfully Treated HIV Type 1-Infected Patients: The ANRS CO3 Aquitaine Cohort |
| Authors: |
Wittkop, Linda; Bitard, Juliette; Lazaro, Estibaliz; Neau, Didier; Bonnet, Fabrice; Mercie, Patrick; Dupon, Michel; Hessamfar, Mojgan; Ventura, Michel; Malvy, Denis; Dabis, François; Pellegrin, Jean-Luc; Moreau, Jean-François; Thiébaut, Rodolphe; Pellegrin, Isabelle; for the Groupe d'Epidémiologie Clinique du SIDA en Aquitaine; F., Dabis; F., Bonnet; S., Bouchet; M., Dupon; G., Chêne; H., Fleury; V., Gaborieau; D., Lacoste; D., Malvy; P., Mercié; I., Pellegrin; P., Morlat; D., Neau; JL., Pellegrin; S., Tchamgoué; R., Thiébaut; M., Bruyand; S., Lawson-Ayayi; L., Wittkop; K., André; F., Bonnal; N., Bernard; L., Caunègre; C., Cazanave; J., Ceccaldi; I., Chossat; C., Courtault; FA., Dauchy; S., De Witte; A., Dupont; P., Duffau; H., Dutronc; S., Farbos; MC., Gemain; Y., Gerard; C., Greib; M., Hessamfar; P., Lataste; E., Lazaro; M., Longy-Boursier; J. P., Meraud; E., Monlun; A., Ochoa; J. L., Pellegrin; T., Pistone; M. C., Receveur; J., Roger-Schmeltz; M. A., Vandenhende; M. O., Vareil; J. F., Viallard; J. F., Moreau; M. E., Lafon; B., Masquelier; P., Trimoulet; D., Breilh; M., Molimard; K., Titier; F., Haramburu; G., Miremont-Salamé; M. J., Blaizeau; M., Decoin; J., Delaune; S., Delveaux; C., D'Ivernois; C., Hanappier; O., Leleux; E., Lenaud; B., Uwamaliya-Nziyumvira; X., Sicard; V., Conte; A., Frosh; S., Geffard; J., Leray; I., Louis; G., Palmer; D., Touchard |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2013 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
HIV/AIDS |
| Description: |
We evaluated the impact of cytomegalovirus (CMV)–induced immune responses, autoimmune-induced immune responses, and microbial translocation on immune activation in 191 human immunodeficiency virus type 1–infected patients from the ANRS CO3 Aquitaine Cohort. All enrolled subjects had achieved long-term virological suppression during receipt of combination antiretroviral therapy (cART). HLA-DR+/CD38+ expression was 16.8% among CD8+ T cells. Independent of age, CD4+ T-cell count, 16S ribosomal DNA load, and regulatory T-cell count, positive results of Quantiferon CMV analysis ( P = .02), positive results of CMV-pp65 enzyme-linked immunosorbent spot analysis ( P = .01), positive results of CMV-pp65–specific CD8+ T-cell analysis ( P = .05), and CMV seropositivity ( P = .01) were associated with a higher percentage of CD8+ T cells that expressed HLA-DR+/CD38+. Autoimmune response and microbial translocation were not associated with immune activation. Therefore, the CMV-induced immune response seems to be associated with chronic immune activation in cART recipients with sustained virological suppression. |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://jid.oxfordjournals.org/cgi/content/short/207/4/622; http://dx.doi.org/10.1093/infdis/jis732 |
| DOI: |
10.1093/infdis/jis732 |
| Availability: |
http://jid.oxfordjournals.org/cgi/content/short/207/4/622; https://doi.org/10.1093/infdis/jis732 |
| Rights: |
Copyright (C) 2013, Infectious Diseases Society of America |
| Accession Number: |
edsbas.F141214C |
| Database: |
BASE |