| Title: |
Improved control of SARS-CoV-2 infection with nucleocapsid-specific antibodies |
| Authors: |
Penaloza-MacMaster, Pablo A; Dangi, Tanushree; Sanchez, Sarah; Class, Jacob; Richner, Michelle; Visvabharathy, Lavanya; Chung, Young Rock; Bentley, Kirsten; Stanton, Richard; Koralnik, Igor Jerome; Richner, Justin; Penaloza-MacMaster, Pablo |
| Source: |
The Journal of Immunology ; volume 210, issue Supplement_1, page 235.26-235.26 ; ISSN 0022-1767 1550-6606 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2023 |
| Description: |
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main antigen in all approved COVID-19 vaccines and is also the only target for monoclonal antibody (mAb) therapies. Immune responses to other viral antigens are generated after SARS-CoV-2 infection, but their contribution to the antiviral response remains unclear. Here, we interrogated whether nucleocapsid-specific antibodies can improve protection against SARS-CoV-2. We first immunized mice with a nucleocapsid-based vaccine and then transferred sera from these mice into naive mice, followed by challenge with SARS-CoV-2. We show that mice that received nucleocapsid-specific sera or a nucleocapsid-specific mAb exhibited enhanced control of SARS-CoV-2. Nucleocapsid-specific antibodies elicited NK-mediated, antibody-dependent cellular cytotoxicity (ADCC) against infected cells. To our knowledge, these findings provide the first demonstration in the coronavirus literature that antibody responses specific to the nucleocapsid protein can improve viral clearance, providing a rationale for the clinical evaluation of nucleocapsid-based mAb therapies to treat COVID-19. NIH (DP2DA051912) |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.4049/jimmunol.210.supp.235.26 |
| Availability: |
https://doi.org/10.4049/jimmunol.210.supp.235.26; https://academic.oup.com/jimmunol/article-pdf/210/Supplement_1/235.26/61481429/235_26.pdf |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.F14B3373 |
| Database: |
BASE |