| Title: |
131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma |
| Authors: |
Saarentaus, Elmo; Fischer-Rasmussen, Kasper; Sliz, Eeva; Bizaki-Vallaskangas, Argyro; Laitinen, Tarja; Toppila-salmi, Sanna; Kankaanranta, Hannu; Kettunen, Johannes; Bønnelykke, Klaus; Palotie, Aarno; Mäkitie, Antti |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2024 |
| Description: |
The coexistence of asthma and chronic rhinosinusitis with nasal polyposis (CRSwNP) is associated with allergic phenotypes, disease severity and failure of first-line treatment for both asthma and CRSwNP. Recent studies have highlighted shared genetic components for these diseases. To better understand this shared component, we performed genome-wide meta-analyses of asthma (n = 71,481), CRSwNP (n = 9626) and chronic rhinosinusitis without nasal polyposis (CRSsNP, n = 15,448) in FinnGen and UKB (685,602 controls). We detected 131 genomic associations, including 17 novel loci for asthma, 33 novel loci for CRSwNP, and one for CRSsNP. A shared impact on asthma and CRSwNP was observed at 71 loci. A cross-trait meta-analysis using all disorders further implicated 17 loci associated with asthma or asthma and CRSwNP. These loci largely cluster into three groups, with a shared risk being the most frequent. We also found 17 nonsynonymous associating variants, including a novel TP63 missense variant linked with CRSwNP (OR = 1.519 [1.331–1.734]). Gene set analyses confirmed enrichment of type 2 inflammation genes, and linked FOXP3 signaling to CRSwNP. Our results highlight new shared and separate genetic pathways for CRSwNP and asthma. These provide several avenues of further investigation in functional and epidemiological follow-up, and evidence for immunological and non-immunological mechanisms behind both diseases. |
| Document Type: |
other/unknown material |
| Language: |
unknown |
| DOI: |
10.21203/rs.3.rs-5001302/v1 |
| Availability: |
http://dx.doi.org/10.21203/rs.3.rs-5001302/v1; https://www.researchsquare.com/article/rs-5001302/v1; https://www.researchsquare.com/article/rs-5001302/v1.html |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.F1EBD1C1 |
| Database: |
BASE |