| Title: |
International validation of the Immunoscore-biopsy (IS B ) to guide selection and monitoring of patients treated with watch-and-wait (WW) strategy for rectal cancer. |
| Authors: |
Pages, Franck; El Sissy, Carine; Kirilovsky, Amos; Custers, Petra; Dizdarevic, Edina; Lagorce, Christine; Castillo-Martin, Mireia; van den Berg, José; Iseas, Soledad; Sanchez Loria, Fernando; Gerard, Jean-Pierre; Dimofte, Gabriel; Perez, Rodrigo O; Habr-Gama, Angelita; Figueiredo, Nuno; Hansen, Torben; Chalabi, Myriam; Galon, Jerome; Beets, Geerard; Zeitoun, Guy |
| Source: |
Pages, F, El Sissy, C, Kirilovsky, A, Custers, P, Dizdarevic, E, Lagorce, C, Castillo-Martin, M, van den Berg, J, Iseas, S, Sanchez Loria, F, Gerard, J-P, Dimofte, G, Perez, R O, Habr-Gama, A, Figueiredo, N, Hansen, T, Chalabi, M, Galon, J, Beets, G & Zeitoun, G 2022, 'International validation of the Immunoscore-biopsy (IS B ) to guide selection and monitoring of patients treated with watch-and-wait (WW) strategy for rectal cancer.', Journal of Clinical Oncology, vol. 40, no. 16. suppl., 3517, pp. 3517. https://doi.org/10.1200/jco.2022.40.16_suppl.3517 |
| Publication Year: |
2022 |
| Collection: |
University of Southern Denmark: Research Output / Syddansk Universitet |
| Description: |
Background: The WW strategy for patients with rectal cancer who achieved a clinical complete response (cCR) after neoadjuvant therapy (nT) allows to avoid major resection and the associated morbidity and mortality. Standardized criteria to select and monitor WW patients, including biomarkers predicting recurrence after nT, are lacking. The prognostic impact of the immune infiltrate in colorectal cancers is now demonstrated and has been implemented into clinics through the Immunoscore, the first standardized digital-pathology-based assay, recommended by academic institutions. We evidenced that an Immunoscore adapted to biopsies (IS B ) performed at diagnosis, predicts the response to nT and the risk of recurrence after nT. Its clinical utility was suggested in a test cohort of WW patients (El Sissy et al., Clin Cancer Res 2020). The aim of this study was to confirm the ability of the IS B to predict clinical outcomes, improve patients’ eligibility for the WW strategy, and optimize a follow-up schedule. Methods: A total of 304 WW patients from 10 centers across 7 countries were included. Tumor biopsies before treatment were immunostained for CD3+ and CD8+ T-cells and converted to IS B using the pre-defined cut-off. The primary endpoint was time-to-recurrence (TTR). Secondary endpoint was disease-free-survival (DFS). As immune response originates in draining lymph nodes, signs of immune activation were carried out in lymph nodes of additional patients managed by radical surgery with complete pathological response (pCR; n = 12) or non-pCR (n = 12) by 3' RNA-Seq and immunofluorescence technologies. Results: High-IS B patients presented with the lowest risk of recurrence after WW. 5-year recurrence-free rates were 97% (92%-100%), 61% (49%-76%), and 56% (44%-73%) with IS B High, Intermediate, and Low, respectively (HR [Low-vs-High] = 14.3, 95% CI 1.8-100). In patients with cCR after nT (n = 209), High-IS B showed a significant association with prolonged TTR and DFS (Logrank P = 0.005 and P = 0.006, respectively). When ... |
| Document Type: |
conference object |
| Language: |
English |
| DOI: |
10.1200/jco.2022.40.16_suppl.3517 |
| Availability: |
https://portal.findresearcher.sdu.dk/da/publications/58ad05b7-5b33-48f2-bac4-c590be1285a1; https://doi.org/10.1200/jco.2022.40.16_suppl.3517 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Accession Number: |
edsbas.F1F44C5D |
| Database: |
BASE |