| Title: |
Risk factors associated with day-30 mortality in patients over 60 years old admitted in ICU for severe COVID-19: the Senior-COVID-Rea Multicentre Survey protocol |
| Authors: |
Falandry, C.; Malapert, A.; Roche, M.; Subtil, F.; Berthiller, J.; Boin, C.; Dubreuil, J.; Ravot, C.; Bitker, L.; Abraham, P.; Collange, V.; Balança, B.; Goutte, S.; Guichon, C.; Gadea, E.; Argaud, L.; Dayde, D.; Jallades, L.; Lepape, A.; Pialat, J. B.; Friggeri, A.; Thiollière, F. |
| Contributors: |
Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Centre Hospitalier Lyon Sud CHU - HCL (CHLS); Hospices Civils de Lyon (HCL); Université de Lyon; Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE); Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS); Délégation à la Recherche Clinique et à l'Innovation Lyon (DRCI); Hôpital de la Croix-Rousse CHU - HCL; Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS); Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon); Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Hôpital Edouard Herriot CHU - HCL; Médipôle Lyon-Villeurbanne; Hôpital neurologique et neurochirurgical Pierre Wertheimer CHU - HCL; Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL); Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); L'Hôpital Nord-Ouest Villefranche sur Saône; Centre Hospitalier Emile Roux AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Service d'anesthésie-réanimation Centre Hospitalier Lyon Sud - HCL; Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL); Centre International de Recherche en Infectiologie - UMR (CIRI); École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Senior-COVID-Rea study Group: Christophe Leroy, Anne-Claire Lukaszewicz, Thomas Rimmelé, Marie Simon, Charles-Hervé Vacheron, Hodane Yonis, Antoine Garnier-Crussard, Max Haïne, Loredana Baboi, Camille Boin, Valérie Cerro, David Dayde, Justine Dubreuil, Carlos El Khoury, Emilie Gadéa-Deschamps, Marie-Catherine Fromont, Audrey Gelot, Anthéa Loïez, Amélie Malapert, Céline Monard, Maya Perrou, Laetitia Paradisi-Prieur, Marion Provent, Mélanie Roche, Gulsum Sahin, Ghyslaine Thao, Marine Thieux. |
| Source: |
ISSN: 2044-6055 ; BMJ Open ; https://www.hal.inserm.fr/inserm-03452093 ; BMJ Open, 2021, 11 (7), pp.e044449. ⟨10.1136/bmjopen-2020-044449⟩. |
| Publisher Information: |
HAL CCSD; BMJ Publishing Group |
| Publication Year: |
2021 |
| Subject Terms: |
COVID-19; geriatric medicine; intensive & critical care; [SDV]Life Sciences [q-bio]; socio; demo |
| Description: |
International audience ; INTRODUCTION: With the spread of COVID-19 epidemic, health plans must be adapted continuously. There is an urgent need to define the best care courses of patients with COVID-19, especially in intensive care units (ICUs), according to their individualised benefit/risk ratio. Since older age is associated with poorer short-term and long-term outcomes, prediction models are needed, that may assist clinicians in their ICU admission decision. Senior-COVID-Rea was designed to evaluate, in patients over 60 years old admitted in ICU for severe COVID-19 disease, the impact of age and geriatric and paraclinical parameters on their mortality 30 days after ICU admission. METHODS AND ANALYSIS: This is a multicentre survey protocol to be conducted in seven hospitals of the Auvergne-Rhône-Alpes region, France. All patients over 60 years old admitted in ICU for severe COVID-19 infection (or their legally acceptable representative) will be proposed to enter the study and to fill in a questionnaire regarding their functional and nutritional parameters 1 month before COVID-19 infection. Paraclinical parameters at ICU admission will be collected: lymphocytes and neutrophils counts, high-fluorescent lymphoid cells and immature granulocytes percentages (Sysmex data), D-dimers, C-reactive protein, lactate dehydrogenase (LDH), creatinine, CT scan for lung extension rate as well as clinical resuscitation scores, and the delay between the first signs of infection and ICU admission. The primary outcome will be the overall survival at day 30 post-ICU admission. The analysis of factors predicting mortality at day 30 will be carried out using univariate and multivariate logistic regressions. Multivariate logistic regression will consider up to 15 factors.The ambition of this trial, which takes into account the different approaches of geriatric vulnerability, is to define the respective abilities of different operational criteria of frailty to predict patients' outcomes. ETHICS AND DISSEMINATION: The study protocol . |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.hal.inserm.fr/inserm-03452093/file/e044449.full.pdf; https://www.hal.inserm.fr/inserm-03452093 |
| Availability: |
https://www.hal.inserm.fr/inserm-03452093/file/e044449.full.pdf; https://www.hal.inserm.fr/inserm-03452093 |
| Rights: |
undefined |
| Accession Number: |
edsbas.F21B2692 |
| Database: |
BASE |