| Title: |
Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study |
| Authors: |
Evans, RA; McAuley, H; Harrison, EM; Shikotra, A; Singapuri, A; Sereno, M; Elneima, O; Docherty, AB; Lone, N; Leavy, OC; Daines, L; Baillie, JK; Brown, JS; Chalder, T; De Soyza, A; Bakerly, ND; Easom, N; Geddes, JR; Greening, NJ; Hart, N; Heaney, LG; Heller, S; Howard, L; Hurst, JR; Jacob, J; Jenkins, RG; Jolley, C; Kerr, S; Kon, OM; Lewis, K; Lord, JM; McCann, GP; Neubauer, S; Openshaw, PJM; Parekh, D; Pfeffer, P; Rahman, NM; Raman, B; Richardson, M; Rowland, M; Semple, MG; Shah, AM; Singh, SJ; Sheikh, A; Thomas, D; Toshner, M; Chalmers, JD; Ho, L-P; Horsley, A; Marks, M; Poinasamy, K; Wain, L; Brightling, CE |
| Publisher Information: |
ELSEVIER SCI LTD |
| Publication Year: |
2021 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
BACKGROUND: The impact of COVID-19 on physical and mental health and employment after hospitalisation with acute disease is not well understood. The aim of this study was to determine the effects of COVID-19-related hospitalisation on health and employment, to identify factors associated with recovery, and to describe recovery phenotypes. METHODS: The Post-hospitalisation COVID-19 study (PHOSP-COVID) is a multicentre, long-term follow-up study of adults (aged ≥18 years) discharged from hospital in the UK with a clinical diagnosis of COVID-19, involving an assessment between 2 and 7 months after discharge, including detailed recording of symptoms, and physiological and biochemical testing. Multivariable logistic regression was done for the primary outcome of patient-perceived recovery, with age, sex, ethnicity, body-mass index, comorbidities, and severity of acute illness as covariates. A post-hoc cluster analysis of outcomes for breathlessness, fatigue, mental health, cognitive impairment, and physical performance was done using the clustering large applications k-medoids approach. The study is registered on the ISRCTN Registry (ISRCTN10980107). FINDINGS: We report findings for 1077 patients discharged from hospital between March 5 and Nov 30, 2020, who underwent assessment at a median of 5·9 months (IQR 4·9-6·5) after discharge. Participants had a mean age of 58 years (SD 13); 384 (36%) were female, 710 (69%) were of white ethnicity, 288 (27%) had received mechanical ventilation, and 540 (50%) had at least two comorbidities. At follow-up, only 239 (29%) of 830 participants felt fully recovered, 158 (20%) of 806 had a new disability (assessed by the Washington Group Short Set on Functioning), and 124 (19%) of 641 experienced a health-related change in occupation. Factors associated with not recovering were female sex, middle age (40-59 years), two or more comorbidities, and more severe acute illness. The magnitude of the persistent health burden was substantial but only weakly associated with the severity of ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
2213-2600 |
| Relation: |
https://hdl.handle.net/11343/310840 |
| Availability: |
https://hdl.handle.net/11343/310840 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.F22369E0 |
| Database: |
BASE |