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Risk categorization using New American College of Cardiology/American Heart Association guidelines for cholesterol management and its relation to alirocumab treatment following acute coronary syndromes

Title: Risk categorization using New American College of Cardiology/American Heart Association guidelines for cholesterol management and its relation to alirocumab treatment following acute coronary syndromes
Authors: Roe, MT; Li, QH; Bhatt, DL; Bittner, VA; Diaz, R; Goodman, SG; Harrington, RA; Jukema, JW; Lopez-Jaramillo, P; Lopes, RD; Louie, MJ; Moriarty, PM; Szarek, M; Vogel, R; White, HD; Zeiher, AM; Baccara-Dinet, MT; Steg, PG; Schwartz, GG; Tricoci, P; Mahaffey, KW; Edelberg, JM; Hanotin, C; Lecorps, G; Moryusef, A; Pordy, R; Sasiela, WJ; Tamby, J-F; Aylward, PE; Drexel, H; Sinnaeve, P; Dilic, M; Gotcheva, NN; Prieto, J-C; Yong, H; Pecin, I; Reiner, Z; Ostadal, P; Poulsen, SH; Viigimaa, M; Nieminen, MS; Danchin, N; Chumburidze, V; Marx, N; Liberopoulos, E; Valdovinos, PCM; Tse, H-F; Kiss, RG; Xavier, D; Zahger, D; Valgimigli, M; Kimura, T; Kim, HS; Kim, S-H; Kedev, S; Erglis, A; Laucevicius, A; Yusoff, K; Lopez, R; Ramos Lopez, GA; Alings, M; Halvorsen, S; Correa Flores, RM; Sy, RG; Budaj, A; Morais, J; Dorobantu, M; Karpov, Y; Ristic, AD; Chua, T; Murin, J; Fras, Z; Dalby, AJ; Tunon, J; De Silva, HA; Hagstrom, E; Muller, C; Chiang, C-E; Sritara, P; Guneri, S; Parkhomenko, A; Ray, KK; Chaitman, B; Kelsey, SF; Olsson, AG; Rouleau, J-L; Simoons, ML; Alexander, K; Meloni, C; Rosenson, R; Sijbrands, EJG; Alexander, JH; Armaganijan, L; Bagai, A; Bahit, MC; Brennan, JM; Clifton, S; DeVore, AD; Deloatch, S; Dickey, S; Dombrowski, K; Ducrocq, G; Eapen, Z; Endsley, P; Eppinger, A; Harrison, RW; Hess, CN; Hlatky, MA; Jordan, JD; Knowles, JW; Kolls, BJ; Kong, DF; Leonardi, S; Lillis, L; Maron, DJ; Marcus, J; Mathews, R; Mehta, RH; Mentz, RJ; Moreira, HG; Patel, CB; Pereira, SB; Perkins, L; Povsic, TJ; Puymirat, E; Jones, WS; Shah, BR; Sherwood, MW; Stringfellow, K; Sujjavanich, D; Toma, M; Van Diepen, SFP; Wilson, MD; Yan, AT-K; Trotter, C; Schiavi, LB; Garrido, M; Alvarisqueta, AF; Sassone, SA; Bordonava, AP; Alves De Lima, AE; Schmidberg, JM; Duronto, EA; Caruso, OC; Novaretto, LP; Angel Hominal, M; Montana, OR; Caccavo, A; Gomez Vilamajo, OA; Lorenzatti, AJ; Cartasegna, LR; Paterlini, GA; Mackinnon, IJ; Caime, GD; Amuchastegui, M; Salomone, R; Codutti, OR; Jure, HO; Bono, JOE; Hrabar, AD; Vallejos, JA; Ahuad Guerrero, RA; Novoa, F; Patocchi, CA; Zaidman, CJ; Giuliano, ME; Dran, RD; Vico, ML; Carnero, GS; Guzman, PN; Medrano Allende, JC; Garcia Brasca, DF; Bustamante Labarta, MH; Nani, S; Blumberg, EDS; Colombo, HR; Liberman, A; Luciardi, HL; Waisman, GD; Berli, MA; Duran, ROG; Cestari, HG; Luquez, HA; Giordano, JA; Saavedra, SS; Zapata, G; Costamagna, O; Llois, S; Waites, JH; Collins, N; Soward, A; Hii, CLS; Shaw, J; Arstall, MA; Horowitz, J; Rogers, JF; Colquhoun, D; Oqueli Flores, RE; Roberts-Thomson, P; Raffel, O; Lehman, SJ; Aroney, C; Coverdale, SGM; Garrahy, PJ; Starmer, G; Sader, M; Carroll, PA; Dick, R; Zweiker, R; Hoppe, U; Huber, K; Berger, R; Weidinger, F; Faes, D; Hermans, K; Pirenne, B; Leone, A; Hoffer, E; Vrolix, MCM; De Wolf, L; Wollaert, B; Castadot, M; Dujardin, K; Beauloye, C; Vervoort, G; Striekwold, H; Convens, C; Roosen, J; Barbato, E; Claeys, M; Cools, F; Terzic, I; Barakovic, F; Midzic, Z; Pojskic, B; Fazlibegovic, E; Durak-Nalbantic, A; Vulic, D; Muslibegovic, A; Goronja, B; Reis, G; Sousa, L; Nicolau, JC; Giorgeto, FE; Silva, RP; Maia, LN; Rech, R; Rossi, PRF; Cerqueira, MJAG; Duda, N; Kalil, R; Kormann, A; Abrantes, JAM; Pimentel Filho, P; Soggia, AP; De Santos, MON; Neuenschwander, F; Bodanese, LC; Michalaros, YL; Eliaschewitz, FG; Vidotti, MH; Leaes, PE; Botelho, RV; Kaiser, S; Fernandes Manenti, ERF; Precoma, DB; Moura Jorge, JC; Silva, PGMDB; Silveira, JA; Saporito, W; Marin Neto, JA; Feitosa, GS; Ritt, LEF; De Souza, JA; Costa, F; Souza, WKSB; Reis, HJL; Machado, L; Aidar Ayoub, JC; Todorov, GV; Nikolov, FP; Velcheva, ES; Tzekova, ML; Benov, HO; Petranov, SL; Tumbev, HS; Shehova-Yankova, NS; Markov, DT; Raev, DH; Mollov, MN; Kichukov, KN; Ilieva-Pandeva, KA; Ivanova, R; Mincheva, VM; Lazov, PV; Dimov, BI; Senaratne, M; Stone, J; Kornder, J; Pearce, S; Dion, D; Savard, D; Pesant, Y; Pandey, A; Robinson, S; Gosselin, G; Vizel, S; Hoag, G; Bourgeois, R; Morisset, A; Sabbah, E; Sussex, B; Kouz, S; MacDonald, P; Diaz, A; Michaud, N; Fell, D; Leung, R; Vuurmans, T; Lai, C; Nigro, F; Davies, R; Nogareda, G; Vijayaraghavan, R; Ducas, J; Lepage, S; Mehta, S; Cha, J; Dupuis, R; Fong, P; Rodes-Cabau, J; Fadlallah, H; Cleveland, D; Thao, H; Bata, I; Hameed, A; Pincetti, C; Potthoff, S; Prieto, JC; Acevedo, M; Aguirre, A; Vejar, M; Yanez, M; Araneda, G; Fernandez, M; Perez, L; Varleta, P; Florenzano, F; Huidobro, L; Raffo, CA; Olivares, C; Nahuelpan, L; Montecinos, H; Chen, J; Dong, Y; Huang, W; Wang, J; Huang, S; Yao, Z; Li, X; Cui, L; Lin, W; Sun, Y; Li, J; Zhang, X; Zhu, H; Chen, D; Huang, L; Dong, S; Su, G; Xu, B; Su, X; Cheng, X; Lin, J; Zong, W; Li, H; Feng, Y; Xu, D; Yang, X; Ke, Y; Lin, X; Zhang, Z; Zheng, Z; Luo, Z; Chen, Y; Ding, C; Zheng, Y; Peng, D; Li, Y; Wei, M; Liu, S; Yu, Y; Qu, B; Jiang, W; Zhou, Y; Zhao, X; Yuan, Z; Guo, Y; Xu, X; Shi, X; Ge, J; Fu, G; Bai, F; Fang, W; Shou, X; Lu, Q; Zhang, R; Zhu, J; Xu, Y; Fan, Z; Li, T; Wu, C; Jaramillo, N; Vallejo, GS; Botia, DCL; Lopez, RB; De Salazar, DIM; Bonfanti, AJC; Higuera, JD; Silva, SIB; Lozada, HJG; Arroyo, JAC; Mendoza, JLA; Ruiz, RLF; Jatin, FGM; Herazo, AS; Parada, JC; Triana, MAU; Strozzi, M; Car, S; Milicic, D; Bencic, ML; Pintaric, H; Prvulovic, D; Sikic, J; Persic, V; Mileta, D; Stambuk, K; Zdravko, B; Tomulic, V; Krstulovic, SM; Starcevic, B; Spinar, J; Horak, D; Stasek, J; Alan, D; Machova, V; Linhart, A; Novotny, V; Kaucak, V; Rokyta, R; Naplava, R; Coufal, Z; Adamkova, V; Podpera, I; Zizka, J; Motovska, Z; Marusincova, I; Svab, P; Heinc, P; Kuchar, J; Povolny, P; Matuska, J; Raungaard, B; Clemmensen, P; Bang, LE; May, O; Bottcher, M; Hove, JD; Frost, L; Gislason, G; Larsen, J; Johansen, PB; Hald, F; Jeppesen, J; Nielsen, T; Kristensen, KS; Walichiewicz, PM; Lomholdt, JD; Klausen, IC; Nielsen, PK; Davidsen, F; Videbaek, L; Soots, M; Vahula, V; Hedman, A; Soopold, U; Martsin, K; Kristjan, A; Taskinen, M-R; Porthan, K; Airaksinen, JK; Juonala, M; Kiviniemi, T; Vikman, S; Posio, P; Taurio, J; Huikuri, H; Kaikkonen, K; Coste, P; Ferrari, E; Morel, O; Montalescot, G; Barone-Rochette, G; Mansourati, J; Cottin, Y; Leclercq, F; Belhassane, A; Delarche, N; Boccara, F; Paganelli, F; Clerc, J; Schiele, F; Aboyans, V; Probst, V; Berland, J; Lefevre, T; Citron, B; Khintibidze, I; Shaburishvili, T; Pagava, Z; Ghlonti, R; Lominadze, Z; Khabeishvili, G; Hemetsberger, R; Rauch-Kroehnert, U; Stratmann, M; Appel, K-F; Schmidt, E; Omran, H; Stellbrink, C; Dorsel, T; Lianopoulos, E; Marx, R; Zirlik, A; Schellenberg, D; Heitzer, T; Laufs, U; Gielen, S; Winkelmann, B; Behrens, S; Sydow, K; Simonis, G; Muenzel, T; Werner, N; Leggewie, S; Boecker, D; Braun-Dullaeus, R; Toursarkissian, N; Jeserich, M; Weissbrodt, M; Schaeufele, T; Weil, J; Voeller, H; Waltenberger, J; Natour, M; Schmitt, S; Steiner, S; Heidenreich, L; Gremmler, U; Killat, H; Rieker, W; Patsilinakos, S; Kartalis, A; Manolis, A; Sionis, D; Skoumas, I; Athyros, V; Vardas, P; Parthenakis, F; Alexopoulos, D; Hahalis, G; Lekakis, J; Hatzitolios, A; Ovando, SRF; Benecke, JLA; De Leon, ERR; Yan, BPY; Siu, DCW; Turi, T; Merkely, B; Ungi, I; Lupkovics, G; Nagy, L; Katona, A; Edes, I; Muller, G; Horvath, I; Kapin, T; Falukozy, J; Kumbla, M; Sandhu, M; Annam, S; Proddutur, NR; Premchand, RK; Mahajan, A; Abhyanakar, AD; Kerkar, P; Govinda, RA; Oomman, A; Sinha, D; Patil, SN; Kahali, D; Sawhney, J; Joshi, AB; Chaudhary, S; Harkut, P; Guha, S; Porwal, S; Jujjuru, S; Pothineni, RB; Monteiro, MR; Khan, A; Iyengar, SS; Grewal, JS; Chopda, M; Fulwani, MC; Patange, A; Chopra, VK; Goyal, NK; Shinde, R; Manakshe, GV; Patki, N; Sethi, S; Munusamy, V; Karna, S; Adhyapak, S; Pandurangi, U; Mathur, R; Kalashetti, S; Bhagwat, A; Raghuraman, B; Yerra, SK; Bhansali, P; Borse, R; Das, S; Abdullakutty, J; Saathe, S; Palimkar, P; Abdullkutty, J; Sathe, S; Atar, S; Shechter, M; Mosseri, M; Arbel, Y; Lotan, C; Rosenschein, U; Katz, A; Henkin, Y; Francis, A; Klutstein, M; Nikolsky, E; Turgeman, Y; Halabi, M; Kornowski, R; Jonas, M; Amir, O; Rozenman, Y; Fuchs, S; Hussein, O; Gavish, D; 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Source: 1589 ; 1578
Publisher Information: American Heart Association
Publication Year: 2019
Collection: Imperial College London: Spiral
Subject Terms: Science & Technology; Life Sciences & Biomedicine; Cardiac & Cardiovascular Systems; Peripheral Vascular Disease; Cardiovascular System & Cardiology; alirocumab; acute coronary syndrome; dyslipidemias; guideline; CARDIOVASCULAR OUTCOMES; STATIN THERAPY; ADDING EZETIMIBE; BENEFIT; EVENTS; PCSK9; Cardiovascular System & Hematology; 1102 Cardiorespiratory Medicine and Haematology; 1103 Clinical Sciences; 1117 Public Health and Health Services
Description: Background: The 2018 US cholesterol management guidelines recommend additional lipid-lowering therapies for secondary prevention in patients with low-density lipoprotein cholesterol ≥70 mg/dL or non−high-density lipoprotein cholesterol ≥100 mg/dL despite maximum tolerated statin therapy. Such patients are considered at very high risk (VHR) based on a history of >1 major atherosclerotic cardiovascular disease (ASCVD) event or a single ASCVD event and multiple high-risk conditions. We investigated the association of US guideline-defined risk categories with the occurrence of ischemic events after acute coronary syndrome and reduction of those events by alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor. Methods: In the ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab), patients with recent acute coronary syndrome and residual dyslipidemia despite optimal statin therapy were randomly assigned to alirocumab or placebo. The primary trial outcome (major adverse cardiovascular events, ie, coronary heart disease death, nonfatal myocardial infarction, ischemic stroke, or hospitalization for unstable angina) was examined according to American College of Cardiology/American Heart Association risk category. Results: Of 18 924 participants followed for a median of 2.8 years, 11 935 (63.1%) were classified as VHR: 4450 (37.3%) had multiple prior ASCVD events and 7485 (62.7%) had 1 major ASCVD event and multiple high-risk conditions. Major adverse cardiovascular events occurred in 14.4% of placebo-treated patients at VHR versus 5.6% of those not at VHR. In the VHR category, major adverse cardiovascular events occurred in 20.4% with multiple prior ASCVD events versus 10.7% with 1 ASCVD event and multiple high-risk conditions. Alirocumab was associated with consistent relative risk reductions in both risk categories (hazard ratio=0.84 for VHR; hazard ratio=0.86 for not VHR; Pinteraction=0.820) and by stratification within ...
Document Type: article in journal/newspaper
Language: English
Relation: Circulation; http://hdl.handle.net/10044/1/78703
DOI: 10.1161/CIRCULATIONAHA.119.042551
Availability: http://hdl.handle.net/10044/1/78703; https://doi.org/10.1161/CIRCULATIONAHA.119.042551
Rights: © 2019 The Authors. Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.
Accession Number: edsbas.F242F5B6
Database: BASE