| Title: |
Resection margin influences survival after pancreatoduodenectomy for distal cholangiocarcinoma |
| Authors: |
Chua, TC; Mittal, A; Arena, J; Sheen, A; Gill, AJ; Samra, JS |
| Publisher Information: |
Elsevier |
| Publication Year: |
2017 |
| Collection: |
Griffith University: Griffith Research Online |
| Subject Terms: |
Clinical sciences; Biliary tract cancer; Cholangiocarcinoma; Cisplatin; Pancreatoduodenectomy; Surgery |
| Description: |
Introduction: Distal cholangiocarcinoma remains a rare cancer associated with a dismal outcome. There is a lack of effective treatment options and where disease is amendable to resection, surgery affords the best potential for long-term survival. The aim of this study was to examine the survival outcomes and prognostic factors of patients undergoing pancreatoduodenectomy for distal cholangiocarcinoma. Methods: Between January 2004 to May 2016, patients who had undergone pancreatoduodenectomy with histologically proven distal cholangiocarcinoma were identified. Clinicopathologic data and survival outcomes were reported. Results: Pancreatoduodenectomy alone was performed in 20 patients (71%) and eight patients (29%) required concomitant vascular resection. The major complication rate was 43% (n = 12). Nineteen patients (68%) had node positive disease. Eighteen patients (64%) had R0 resection. The median survival was 36 months (95%CI 9.7 to 63.8) and 5-year survival rate was 24%. Univariate analysis identified ASA (P < 0.001), tumor grade (P = 0.009) and margin status (P = 0.042) as prognostic factors associated with survival. Conclusion: Long-term survival may be achieved in selected patients undergoing pancreatoduodenectomy for distal cholangiocarcinoma, especially in patients who achieved an R0 resection. ; No Full Text |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
The American Journal of Surgery; Chua, TC; Mittal, A; Arena, J; Sheen, A; Gill, AJ; Samra, JS, Resection margin influences survival after pancreatoduodenectomy for distal cholangiocarcinoma, The American Journal of Surgery, 2017, 213 (6), pp. 1072-1076; https://hdl.handle.net/10072/405938 |
| DOI: |
10.1016/j.amjsurg.2016.09.049 |
| Availability: |
https://hdl.handle.net/10072/405938; https://doi.org/10.1016/j.amjsurg.2016.09.049 |
| Rights: |
open access |
| Accession Number: |
edsbas.F24EB976 |
| Database: |
BASE |