| Title: |
Long non-coding RNAs: definitions, functions, challenges and recommendations |
| Authors: |
Mattick, JS; Amaral, PP; Carninci, P; Carpenter, S; Chang, HY; Chen, LL; Chen, R; Dean, C; Dinger, ME; Fitzgerald, KA; Gingeras, TR; Guttman, M; Hirose, T; Huarte, M; Johnson, R; Kanduri, C; Kapranov, P; Lawrence, JB; Lee, JT; Mendell, JT; Mercer, TR; Moore, KJ; Nakagawa, S; Rinn, JL; Spector, DL; Ulitsky, I; Wan, Y; Wilusz, JE; Wu, M |
| Source: |
urn:ISSN:1471-0072 ; urn:ISSN:1471-0080 ; Nature Reviews Molecular Cell Biology, 24, 6, 430-447 |
| Publisher Information: |
Springer Nature |
| Publication Year: |
2023 |
| Collection: |
UNSW Sydney (The University of New South Wales): UNSWorks |
| Subject Terms: |
31 Biological Sciences; 3102 Bioinformatics and Computational Biology; Genetics; Human Genome; 1.1 Normal biological development and functioning; Generic health relevance; RNA; Long Noncoding; Cell Nucleus; Chromatin; Regulatory Sequences; Nucleic Acid; RNA Polymerase II; anzsrc-for: 31 Biological Sciences; anzsrc-for: 3102 Bioinformatics and Computational Biology; anzsrc-for: 06 Biological Sciences; anzsrc-for: 11 Medical and Health Sciences; anzsrc-for: 32 Biomedical and clinical sciences; anzsrc-for: 42 Health sciences |
| Description: |
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes of complex organisms. The term ‘lncRNAs’ encompasses RNA polymerase I (Pol I), Pol II and Pol III transcribed RNAs, and RNAs from processed introns. The various functions of lncRNAs and their many isoforms and interleaved relationships with other genes make lncRNA classification and annotation difficult. Most lncRNAs evolve more rapidly than protein-coding sequences, are cell type specific and regulate many aspects of cell differentiation and development and other physiological processes. Many lncRNAs associate with chromatin-modifying complexes, are transcribed from enhancers and nucleate phase separation of nuclear condensates and domains, indicating an intimate link between lncRNA expression and the spatial control of gene expression during development. lncRNAs also have important roles in the cytoplasm and beyond, including in the regulation of translation, metabolism and signalling. lncRNAs often have a modular structure and are rich in repeats, which are increasingly being shown to be relevant to their function. In this Consensus Statement, we address the definition and nomenclature of lncRNAs and their conservation, expression, phenotypic visibility, structure and functions. We also discuss research challenges and provide recommendations to advance the understanding of the roles of lncRNAs in development, cell biology and disease. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
http://purl.org/au-research/grants/arc/DP210103233; https://hdl.handle.net/1959.4/108037 |
| DOI: |
10.1038/s41580-022-00566-8 |
| Availability: |
https://hdl.handle.net/1959.4/108037; https://doi.org/10.1038/s41580-022-00566-8 |
| Rights: |
metadata only access ; http://purl.org/coar/access_right/c_14cb ; CC-BY ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.F2CEAE2C |
| Database: |
BASE |