| Title: |
Single-Component Electroactive Polymer Architectures for Non-Enzymatic Glucose Sensing |
| Authors: |
Kousseff, Christina J.; Wustoni, Shofarul; Silva, Raphaela K. S.; Lifer, Ariel; Savva, Achilleas; Frey, Gitti L.; Inal, Sahika; Nielsen, Christian B. |
| Contributors: |
Organic Bioelectronics Laboratory Biological and Environmental Science and Engineering King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Saudi Arabia; Biological, Environmental Sciences and Engineering; Biological and Environmental Science and Engineering (BESE) Division; Bioengineering; Bioengineering Program; Environmental Science and Engineering; Environmental Science and Engineering Program; Department of Chemistry Queen Mary University of London Mile End Road London E1 4NS UK; Department of Materials Science and Engineering Technion–Israel Institute of Technology Haifa 32000 Israel; Bioelectronics Section Department of Microelectronics Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) Delft University of Technology Delft 2628 CD The Netherlands |
| Publisher Information: |
Wiley |
| Publication Year: |
2024 |
| Collection: |
King Abdullah University of Science and Technology: KAUST Repository |
| Description: |
Organic mixed ionic-electronic conductors (OMIECs) have emerged as promising materials for biological sensing, owing to their electrochemical activity, stability in an aqueous environment, and biocompatibility. Yet, OMIEC-based sensors rely predominantly on the use of composite matrices to enable stimuli-responsive functionality, which can exhibit issues with intercomponent interfacing. In this study, an approach is presented for non-enzymatic glucose detection by harnessing a newly synthesized functionalized monomer, EDOT-PBA. This monomer integrates electrically conducting and receptor moieties within a single organic component, obviating the need for complex composite preparation. By engineering the conditions for electrodeposition, two distinct polymer film architectures are developed: pristine PEDOT-PBA and molecularly imprinted PEDOT-PBA. Both architectures demonstrated proficient glucose binding and signal transduction capabilities. Notably, the molecularly imprinted polymer (MIP) architecture demonstrated faster stabilization upon glucose uptake while it also enabled a lower limit of detection, lower standard deviation, and a broader linear range in the sensor output signal compared to its non-imprinted counterpart. This material design not only provides a robust and efficient platform for glucose detection but also offers a blueprint for developing selective sensors for a diverse array of target molecules, by tuning the receptor units correspondingly. ; C.J.K. and S.W. contributed equally to this work. The authors acknowledge the European Commission for financial support through the MITICS H2020-EU-FET Open project (No. 964677). The authors acknowledge Dr. Zixuan Henry Lu and Prof. Róisín Owens from the University of Cambridge for supporting initial QCM-D measurements. This publication was based upon work supported by King Abdullah University of Science and Technology Research Funding (KRF) under award No. ORA-2021-CRG10-4650. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| ISSN: |
2198-3844 |
| Relation: |
2-s2.0-85188303489; Advanced Science; http://hdl.handle.net/10754/697820 |
| DOI: |
10.1002/advs.202308281 |
| Availability: |
http://hdl.handle.net/10754/697820; https://doi.org/10.1002/advs.202308281 |
| Rights: |
Archived with thanks to Advanced Science under a Creative Commons license, details at: http://creativecommons.org/licenses/by/4.0/ ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.F2F65071 |
| Database: |
BASE |