| Title: |
Diagnostic accuracy of sputum gene xpert MTB /RIF and stool gene xpert-ultra in children with pulmonary tuberculosis in a resource constraint country |
| Authors: |
Bhadra, Shima; Rahman, Atiar; alam, Rubaiyat; Mahbuba, Sharmin |
| Source: |
International Journal of Contemporary Pediatrics; Vol. 11 No. 11 (2024): November 2024; 1506-1511 ; 2349-3291 ; 2349-3283 |
| Publisher Information: |
Medip Academy |
| Publication Year: |
2024 |
| Subject Terms: |
Children; Sputum gene Xpert MTB/RIF; Stool Gene Xpert ultra; Tuberculosis |
| Description: |
Background: Diagnosis of tuberculosis in children remains a challenge especially in resource limited settings. This study aimed to determine the diagnostic accuracy of sputum Gene Xpert MTB/RIF and stool Xpert-Ultra for the diagnosis of PTB. Methods: This retrospective study was conducted in paediatric pulmonology ward of Bangabandhu Sheikh Mujib Medical University from March 2022 to December 2023.Consecuative 85 children aged 0-14 years with presumptive pulmonary tuberculosis (PTB) who provided both sputum and stool sample for GeneXpert and Xpert-Ultra respectively were included in the study. Diagnosis of PTB was confirmed by clinical, radiological, bacteriological or molecular evidence and taken as reference. Result: A total 119 children were enrolled; 85 of whom complete microbiological examination. PTB was diagnosed in 25 children. Of these 18(18/25) children was found positive in stool Xpert -Ultra and 6 children were tested positive by sputum /GA Gene Xpert MTB/RIF. All 6 positive sputum/GA samples were also positive on stool testing. The rate of concordance between stool and sputum was moderate with a kappa value of 0.441 (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://www.ijpediatrics.com/index.php/ijcp/article/view/6285/3840; https://www.ijpediatrics.com/index.php/ijcp/article/view/6285 |
| DOI: |
10.18203/2349-3291.ijcp20243073 |
| Availability: |
https://www.ijpediatrics.com/index.php/ijcp/article/view/6285; https://doi.org/10.18203/2349-3291.ijcp20243073 |
| Rights: |
Copyright (c) 2024 International Journal of Contemporary Pediatrics |
| Accession Number: |
edsbas.F32A0457 |
| Database: |
BASE |