| Title: |
Sex-Related Differences and Factors Associated with Peri-Procedural and 1 Year Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian Registry |
| Authors: |
Martelli, Eugenio; Zamboni, Matilde; Sotgiu, Giovanni; Saderi, Laura; Federici, Massimo; Sangiorgi, Giuseppe M; Puci, Mariangela V; Martelli, Allegra R; Messina, Teresa; Frigatti, Paolo; Borrelli, Maria Pia; Ruotolo, Carlo; Ficarelli, Ilaria; Rubino, Paolo; Pezzo, Francesco; Carbonari, Luciano; Angelini, Andrea; Galeazzi, Edoardo; Di Pinto, Luca Calia; Fiore, Franco M; Palmieri, Armando; Ventoruzzo, Giorgio; Mazzitelli, Giulia; Ragni, Franco; Bozzani, Antonio; Forliti, Enzo; Castagno, Claudio; Volpe, Pietro; Massara, Mafalda; Moniaci, Diego; Pagliasso, Elisa; Peretti, Tania; Ferrari, Mauro; Troisi, Nicola; Modugno, Piero; Maiorano, Maurizio; Bracale, Umberto M; Panagrosso, Marco; Monaco, Mario; Giordano, Giovanni; Natalicchio, Giuseppe; Biello, Antonella; Celoria, Giovanni M; Amico, Alessio; Di Bartolo, Mauro; Martelli, Massimiliano; Munaó, Roberta; Razzano, Davide; Colacchio, Giovanni; Bussetti, Francesco; Lanza, Gaetano; Cardini, Antonio; Di Benedetto, Bartolomeo; De Laurentis, Mario; Taurino, Maurizio; Sirignano, Pasqualino; Cappiello, Pierluigi; Esposito, Andrea; Trimarchi, Santi; Romagnoli, Silvia; Padricelli, Andrea; Giudice, Giorgio; Crinisio, Adolfo; Di Nardo, Giovanni; Battaglia, Giuseppe; Tringale, Rosario; De Vivo, Salvatore; Compagna, Rita; Tolva, Valerio S; D'Alessio, Ilenia; Curci, Ruggiero; Giovannetti, Simona; D'Arrigo, Giuseppe; Basile, Giusi; Frigerio, Dalmazio; Veraldi, Gian Franco; Mezzetto, Luca; Ippoliti, Arnaldo; Oddi, Fabio M; Settembrini, Alberto M |
| Contributors: |
Martelli, E; Zamboni, M; Sotgiu, G; Saderi, L; Federici, M; Sangiorgi, Gm; Puci, Mv; Martelli, Ar; Messina, T; Frigatti, P; Borrelli, Mp; Ruotolo, C; Ficarelli, I; Rubino, P; Pezzo, F; Carbonari, L; Angelini, A; Galeazzi, E; Di Pinto, Lc; Fiore, Fm; Palmieri, A; Ventoruzzo, G; Mazzitelli, G; Ragni, F; Bozzani, A; Forliti, E; Castagno, C; Volpe, P; Massara, M; Moniaci, D; Pagliasso, E; Peretti, T; Ferrari, M; Troisi, N; Modugno, P; Maiorano, M; Bracale, Um; Panagrosso, M; Monaco, M; Giordano, G; Natalicchio, G; Biello, A; Celoria, Gm; Amico, A; Di Bartolo, M; Martelli, M; Munaó, R; Razzano, D; Colacchio, G; Bussetti, F; Lanza, G; Cardini, A; Di Benedetto, B; De Laurentis, M; Taurino, M; Sirignano, P; Cappiello, P; Esposito, A; Trimarchi, S; Romagnoli, S; Padricelli, A; Giudice, G; Crinisio, A; Di Nardo, G; Battaglia, G; Tringale, R; De Vivo, S; Compagna, R; Tolva, V; D'Alessio, I; Curci, R; Giovannetti, S; D'Arrigo, G; Basile, G; Frigerio, D; Veraldi, Gf; Mezzetto, L; Ippoliti, A; Oddi, Fm; Settembrini, Am |
| Publisher Information: |
MDPI |
| Publication Year: |
2023 |
| Collection: |
Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| Subject Terms: |
age; chronic limb-threatening ischemia; limb salvage; outcome; sex; Settore MED/09 - MEDICINA INTERNA |
| Description: |
Background: Identifying sex-related differences/variables associated with 30 day/1 year mortality in patients with chronic limb-threatening ischemia (CLTI). Methods: Multicenter/retrospective/observational study. A database was sent to all the Italian vascular surgeries to collect all the patients operated on for CLTI in 2019. Acute lower-limb ischemia and neuropathic-diabetic foot are not included. Follow-up: One year. Data on demographics/comorbidities, treatments/outcomes, and 30 day/1 year mortality were investigated. Results: Information on 2399 cases (69.8% men) from 36/143 (25.2%) centers. Median (IQR) age: 73 (66-80) and 79 (71-85) years for men/women, respectively (p < 0.0001). Women were more likely to be over 75 (63.2% vs. 40.1%, p=0.0001). More men smokers (73.7% vs. 42.2%, p < 0.0001), are on hemodialysis (10.1% vs. 6.7%, p=0.006), affected by diabetes (61.9% vs. 52.8%, p < 0.0001), dyslipidemia (69.3% vs. 61.3%, p < 0.0001), hypertension (91.8% vs. 88.5%, p=0.011), coronaropathy (43.9% vs. 29.4%, p < 0.0001), bronchopneumopathy (37.1% vs. 25.6%, p < 0.0001), underwent more open/hybrid surgeries (37.9% vs. 28.8%, p < 0.0001), and minor amputations (22% vs. 13.7%, p < 0.0001). More women underwent endovascular revascularizations (61.6% vs. 55.2%, p=0.004), major amputations (9.6% vs. 6.9%, p=0.024), and obtained limb-salvage if with limited gangrene (50.8% vs. 44.9%, p=0.017). Age > 75 (HR = 3.63, p = 0.003) is associated with 30 day mortality. Age > 75 (HR = 2.14, p < 0.0001), nephropathy (HR = 1.54, p < 0.0001), coronaropathy (HR = 1.26, p = 0.036), and infection/necrosis of the foot (dry, HR = 1.42, p = 0.040; wet, HR = 2.04, p < 0.0001) are associated with 1 year mortality. No sex-linked difference in mortality statistics. Conclusion: Women exhibit fewer comorbidities but are struck by CLTI when over 75, a factor associated with short- and mid-term mortality, explaining why mortality does not statistically differ between the sexes. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36836550; info:eu-repo/semantics/altIdentifier/wos/WOS:000940752800001; volume:13; issue:2; firstpage:316; journal:JOURNAL OF PERSONALIZED MEDICINE; https://hdl.handle.net/2108/322435 |
| DOI: |
10.3390/jpm13020316 |
| Availability: |
https://hdl.handle.net/2108/322435; https://doi.org/10.3390/jpm13020316 |
| Accession Number: |
edsbas.F32CA761 |
| Database: |
BASE |