| Title: |
Translational veterinary epilepsy : A win-win situation for human and veterinary neurology |
| Authors: |
Charalambous, Marios; Fischer, Andrea; Potschka, Heidrun; Walker, Matthew C.; Raedt, Robrecht; Vonck, Kristl; Boon, Paul; Lohi, Hannes; Loescher, Wolfgang; Worrell, Gregory; Leeb, Tosso; McEvoy, Andrew; Striano, Pasquale; Kluger, Gerhard; Galanopoulou, Aristea S.; Volk, Holger A.; Bhatti, Sofie F. M. |
| Contributors: |
Helsinki One Health (HOH); Hannes Tapani Lohi / Principal Investigator; Veterinary Genetics; Veterinary Biosciences; Medicum; Department of Medical and Clinical Genetics |
| Publisher Information: |
Bailliere Tindall Ltd |
| Publication Year: |
2024 |
| Collection: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| Subject Terms: |
Dog; Human; Nervous system; Seizures; Therapy; Veterinary science |
| Description: |
Epilepsy is a challenging multifactorial disorder with a complex genetic background. Our current understanding of the pathophysiology and treatment of epilepsy has substantially increased due to animal model studies, including canine studies, but additional basic and clinical research is required. Drug-resistant epilepsy is an important problem in both dogs and humans, since seizure freedom is not achieved with the available antiseizure medications. The evaluation and exploration of pharmacological and particularly non-pharmacological thera-peutic options need to remain a priority in epilepsy research. Combined efforts and sharing knowledge and expertise between human medical and veterinary neurologists are important for improving the treatment out-comes or even curing epilepsy in dogs. Such interactions could offer an exciting approach to translate the knowledge gained from people and rodents to dogs and vice versa. In this article, a panel of experts discusses the similarities and knowledge gaps in human and animal epileptology, with the aim of establishing a common framework and the basis for future translational epilepsy research. ; Peer reviewed |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://hdl.handle.net/10138/571136; 000946237200001 |
| Availability: |
https://hdl.handle.net/10138/571136 |
| Rights: |
cc_by_nc ; info:eu-repo/semantics/openAccess ; openAccess |
| Accession Number: |
edsbas.F3351BAA |
| Database: |
BASE |