| Title: |
Dysregulation of microRNAs in adrenocortical tumors. |
| Authors: |
Singh, Puneet; Soon, Patsy S H; Feige, Jean-Jacques; Chabre, Olivier; Zhao, Jing Ting; Cherradi, Nadia; Lalli, Enzo; Sidhu, Stan B |
| Contributors: |
Department of Surgery, Bankstown Hospital and South Western Sydney Clinical School; University of New South Wales Sydney (UNSW); Cancer Genetics Unit, Hormones & Cancer Group; The University of Sydney; Biology of Cancer and Infection; Université Joseph Fourier - Grenoble 1 (UJF); Biologie du Cancer et de l'Infection (BCI); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 )-Institut de Recherche Interdisciplinaire de Grenoble (IRIG); Direction de Recherche Fondamentale (CEA) (DRF (CEA)); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA); CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble (CHUGA); Institut de pharmacologie moléculaire et cellulaire (IPMC); Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA); Université Nice Sophia Antipolis (1965 - 2019) (UNS); Department of Endocrine and Oncology Surgery; Royal North Shore Hospital (RNSH) |
| Source: |
ISSN: 0303-7207. |
| Publisher Information: |
CCSD; Elsevier |
| Publication Year: |
2012 |
| Collection: |
Université Grenoble Alpes: HAL |
| Subject Terms: |
MESH: Adrenal Cortex Neoplasms; MESH: Adrenocortical Adenoma; MESH: Animals; MESH: Disease-Free Survival; MESH: Gene Expression Regulation; Neoplastic; MESH: Humans; MESH: MicroRNAs; MESH: RNA; Neoplasm; MESH: Survival Rate; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; MicroRNAs (miRNAs) are short non-coding RNAs that are involved in the epigenetic regulation of cellular processes. Different malignancies are often associated with the deregulation of specific sets of miRNAs. The prognosis of adrenocortical cancers (ACCs) is very poor as compared to adrenocortical adenomas (ACAs), and even within ACCs there are cases with better disease specific survival. An improved understanding of the pathobiology of this disease will therefore be useful in facilitating better management of ACCs as well as distinguishing high risk versus low risk subgroups. One third of coding genes are regulated by miRNAs and therefore changes in miRNA expression may be associated with cancer development and progression. In this review we summarize the current understanding of miRNAs in adrenocortical tumors, and highlight their potential in differentiating between ACCs and ACAs, risk stratification and prognosis. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/21996374; PUBMED: 21996374 |
| DOI: |
10.1016/j.mce.2011.09.041 |
| Availability: |
https://hal.science/hal-00728034; https://doi.org/10.1016/j.mce.2011.09.041 |
| Accession Number: |
edsbas.F34E89F5 |
| Database: |
BASE |