| Title: |
Impact of epinephrine on ropivacaine pharmacokinetics in TAP blocks: a randomized controlled trial |
| Authors: |
Rozier, Romain; Capdevila, Xavier; Le Louarn, Eric; Balbo, Juliette; Lavrut, Thibaud; Baque, Patrick; Perus, Olivier; Destere, Alexandre; Maurice-Szamburski, Axel; Le Guennec, Yannis |
| Contributors: |
Centre méditerranéen de médecine moléculaire (C3M); Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UniCA); Département d'Anesthésie-Réanimation Gui de Chauliac - CHU Montpellier; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Hôpital Gui de Chauliac CHU Montpellier; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); OcciTRAUMA network; Hôpital Pasteur Nice (CHU); Centre Hospitalier Universitaire de Nice (CHU Nice); Modèles et algorithmes pour l’intelligence artificielle (MAASAI); Centre Inria d'Université Côte d'Azur; Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Laboratoire Jean Alexandre Dieudonné (LJAD); Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA)-Scalable and Pervasive softwARe and Knowledge Systems (Laboratoire I3S - SPARKS); Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S); Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S); Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA)-Centre National de la Recherche Scientifique (CNRS); CHU Nice Cimiez; Hôpital Cimiez Nice (CHU); Centre de Radiofréquences, Optique et Micro-nanoélectronique des Alpes (CROMA); Université Savoie Mont Blanc (USMB Université de Savoie Université de Chambéry )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP); Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA) |
| Source: |
ISSN: 1098-7339. |
| Publisher Information: |
CCSD; bmj publishing group |
| Publication Year: |
2025 |
| Collection: |
Université Savoie Mont Blanc: HAL |
| Subject Terms: |
Pharmacokinetics; Intoxication; Intensive care unit; Drug interactions; Antiepileptics; [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology |
| Description: |
International audience ; Background Ropivacaine is commonly used in abdominal wall blocks due to its safety profile, and the addition of epinephrine is hypothesized to prolong analgesic duration and reduce systemic absorption. However, previous studies have been limited by non-weight-adjusted dosing and potential pharmacokinetic interactions, and inadequate investigation of the free form of ropivacaine. Objective To characterize and compare the pharmacokinetics of total and free ropivacaine administered at a weight-adjusted dose of 1 mg/kg in Transversus Abdominis Plane (TAP) blocks, with and without epinephrine (1:200 000; 5 µg/mL). Methods In this randomized controlled trial, 40 patients undergoing laparoscopic colectomy received bilateral TAP blocks with ropivacaine alone (TAP/E−) or ropivacaine with epinephrine (TAP/E+). Pharmacokinetic parameters, including maximum plasma concentration (Cmax), time to Cmax (Tmax), and area under the concentration-time curve, were assessed over 240 min. Secondary outcomes included α₁-acid glycoprotein (AGP), analgesia, safety, and mean plasma concentration (Cmean). Results The mean Cmax in the TAP/E+ group (0.531±0.245 µg/mL) was not significantly different from that in the TAP/E− group (0.746±0.428 µg/mL). Epinephrine significantly prolonged Tmax (165 vs 55.9 min in TAP/E−, p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39694791; PUBMED: 39694791 |
| DOI: |
10.1136/rapm-2025-106500 |
| Availability: |
https://hal.science/hal-05155972; https://doi.org/10.1136/rapm-2025-106500 |
| Rights: |
http://creativecommons.org/licenses/by-nc/ |
| Accession Number: |
edsbas.F37C765C |
| Database: |
BASE |