| Title: |
Liver Resection vs Nonsurgical Treatments for Patients With Early Multinodular Hepatocellular Carcinoma |
| Authors: |
Vitale, Alessandro; Romano, Pierluigi; Cillo, Umberto; null, null; Busti, Marco; Nezi, Giulia; De Carlis, Riccardo; Ratti, Francesca; Milana, Flavio; Donadon, Matteo; Marinelli, Laura; Razionale, Francesco; Carissimi, Francesca; Scotti, Mauro Alessandro; Ciuli, Cristina; De Peppo, Valerio; Russolillo, Nadia; Giuffrida, Mauro; De Stefano, Francesca; Peverada, Jacopo; Larghi Laureiro, Zoe; Franceschi, Angelo; Pelizzo, Patrizia; Marchitelli, Ivan; Casella, Annachiara; Manzoni, Alberto; Malagnino, Alessia; Calcagno, Pietro; Cammarata, Francesco; Pennacchi, Luca; Cosola, Davide; Corleone, Pio; Cucchetti, Alessandro; Mantovani, Guido; Notte, Francesca; Montuori, Mauro; Allegrini, Gloria; Cammà, Calogero; Celsa, Ciro; Giuffrida, Paolo; Giacchetto, Carmelo Marco; Rancatore, Gabriele; Grassin, Maria Vittoria; Ciccia, Roberta; Grova, Alessandro; Salvato, Mauro; Biasini, Elisabetta; Olivani, Andrea; Chen, Rusi; Granito, Alessandro; Piscaglia, Fabio; Stefanini, Bernardo; Tovoli, Francesco; Biselli, Maurizio; Bucci, Laura; Lani, Lorenzo; Stefanini, Benedetta; Bevilacqua, Vittoria; Berardinelli, Dante; Borghi, Alberto; Casadei Gardini, Andrea; Conti, Fabio; Dall'Aglio, Anna Chiara; Ercolan, Giorgio; Campani, Claudia; Di Bonaventura, Chiara; Gitto, Stefano; Franzè, Maria Stella; Sauchella, Assunta; Coccoli, Pietro; Malerba, Antonio; Capasso, Mario; Guarino, Maria; Lauria, Valentina; Ghittoni, Giorgia; Pelecca, Giorgio; Sartori, Anna; Imondi, Angela; Penzo, Barbara; Inno, Alessandro; Marchetti, Fabiana; Di Bucchianico, Alessandro; Dajti, Elton; Ravaioli, Federico; Plaz Torres, Maria Corina; Pieri, Giulia; Olivieri, Filippo; Romagnoli, Veronica; de Matthaeis, Nicoletta; Cela, Ester Marina; Facciorusso, Antonio; Ponziani, Francesca Romana; Lauterio, Andrea; Sangiovanni, Angelo; Cabibbo, Giuseppe; Missale, Gabriele; Marseglia, Mariarosaria; Trevisani, Franco; Foschi, Francesco Giuseppe; Cipriani, Federica; Famularo, Simone; Marra, Fabio; Saitta, Carlo; Serenari, Matteo; Vidili, Gianpaolo; Morisco, Filomena; Caturelli, Eugenio; Mega, Andrea; Pelizzaro, Filippo; Nicolini, Daniele; Ardito, Francesco; Garancini, Mattia; Masotto, Alberto; Baroni, Gianluca Svegliati; Azzaroli, Francesco; Giannini, Edoardo; Perri, Pasquale; Scarinci, Andrea; Fontana, Andrea Pierluigi; Brunetto, Maurizia Rossana; Iaria, Maurizio; Di Marco, Maria; Nardone, Gerardo; Dominioni, Tommaso; Lai, Quirino; Ferrari, Cecilia; Rapaccini, Gian Ludovico; Rodolfo, Sacco; Romano, Maurizio; Conci, Simone; Zoli, Marco; Conticchio, Maria; Zanello, Matteo; Zimmitti, Giuseppe; Fumagalli, Luca; Troci, Albert; Germani, Paola; Gasbarrini, Antonio; La Barba, Giuliano; De Angelis, Michela; Patauner, Stefan; Molfino, Sarah; Zago, Mauro; Pinotti, Enrico; Frigo, Anna Chiara; Baiocchi, Gian Luca; Frena, Antonio; Boccia, Luigi; Ercolani, Giorgio; Tarchi, Paola; Crespi, Michele; Chiarelli, Marco; Abu Hilal, Moh'd; Cescon, Matteo; Memeo, Riccardo; Ruzzenente, Andrea; Zanus, Giacomo; Griseri, Guido; Rossi, Massimo; Maestri, Marcello; Della Valle, Raffaele; Ferrero, Alessandro; Grazi, Gian Luca; Romano, Fabrizio; Giuliante, Felice; Vivarelli, Marco; Jovine, Elio; Torzilli, Guido; Aldrighetti, Luca; De Carlis, Luciano |
| Contributors: |
Vitale, Alessandro; Romano, Pierluigi; Cillo, Umberto; Null, Null; Busti, Marco; Nezi, Giulia; De Carlis, Riccardo; Ratti, Francesca; Milana, Flavio; Donadon, Matteo; Marinelli, Laura; Razionale, Francesco; Carissimi, Francesca; Scotti, Mauro Alessandro; Ciuli, Cristina; De Peppo, Valerio; Russolillo, Nadia; Giuffrida, Mauro; De Stefano, Francesca; Peverada, Jacopo; Larghi Laureiro, Zoe; Franceschi, Angelo; Pelizzo, Patrizia; Marchitelli, Ivan; Casella, Annachiara; Manzoni, Alberto; Malagnino, Alessia; Calcagno, Pietro; Cammarata, Francesco; Pennacchi, Luca; Cosola, Davide; Corleone, Pio; Cucchetti, Alessandro; Mantovani, Guido; Notte, Francesca; Montuori, Mauro; Allegrini, Gloria; Cammà, Calogero; Celsa, Ciro; Giuffrida, Paolo; Giacchetto, Carmelo Marco; Rancatore, Gabriele; Grassin, Maria Vittoria; Ciccia, Roberta; Grova, Alessandro; Salvato, Mauro; Biasini, Elisabetta; Olivani, Andrea; Chen, Rusi; Granito, Alessandro; Piscaglia, Fabio; Stefanini, Bernardo; Tovoli, Francesco; Biselli, Maurizio; Bucci, Laura; Lani, Lorenzo; Stefanini, Benedetta; Bevilacqua, Vittoria; Berardinelli, Dante; Borghi, Alberto; Casadei Gardini, Andrea; Conti, Fabio; Dall'Aglio, Anna Chiara; Ercolan, Giorgio; Campani, Claudia; Di Bonaventura, Chiara; Gitto, Stefano; Franzè, Maria Stella; Sauchella, Assunta; Coccoli, Pietro; Malerba, Antonio; Capasso, Mario; Guarino, Maria; Lauria, Valentina; Ghittoni, Giorgia; Pelecca, Giorgio; Sartori, Anna; Imondi, Angela; Penzo, Barbara; Inno, Alessandro; Marchetti, Fabiana; Di Bucchianico, Alessandro; Dajti, Elton; Ravaioli, Federico; Plaz Torres, Maria Corina; Pieri, Giulia; Olivieri, Filippo; Romagnoli, Veronica; De Matthaeis, Nicoletta; Cela, Ester Marina; Facciorusso, Antonio; Ponziani, Francesca Romana; Lauterio, Andrea; Sangiovanni, Angelo; Cabibbo, Giuseppe; Missale, Gabriele; Marseglia, Mariarosaria; Trevisani, Franco |
| Publisher Information: |
AMER MEDICAL ASSOC |
| Publication Year: |
2024 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Description: |
Importance The 2022 Barcelona Clinic Liver Cancer algorithm currently discourages liver resection (LR) for patients with multinodular hepatocellular carcinoma (HCC) presenting with 2 or 3 nodules that are each 3 cm or smaller. Objective To compare the efficacy of liver resection (LR), percutaneous radiofrequency ablation (PRFA), and transarterial chemoembolization (TACE) in patients with multinodular HCC. Design, Setting, and Participants This cohort study is a retrospective analysis conducted using data from the HE.RC.O.LE.S register (n = 5331) for LR patients and the ITA.LI.CA database (n = 7056) for PRFA and TACE patients. A matching-adjusted indirect comparison (MAIC) method was applied to balance data and potential confounding factors between the 3 groups. Included were patients from multiple centers from 2008 to 2020; data were analyzed from January to December 2023. Interventions LR, PRFA, or TACE. Main Outcomes and Measures Survival rates at 1, 3, and 5 years were calculated. Cox MAIC-weighted multivariable analysis and competing risk analysis were used to assess outcomes. Results A total of 720 patients with early multinodular HCC were included, 543 males (75.4%), 177 females (24.6%), and 350 individuals older than 70 years (48.6%). There were 296 patients in the LR group, 240 who underwent PRFA, and 184 who underwent TACE. After MAIC, LR exhibited 1-, 3-, and 5-year survival rates of 89.11%, 70.98%, and 56.44%, respectively. PRFA showed rates of 94.01%, 65.20%, and 39.93%, while TACE displayed rates of 90.88%, 48.95%, and 29.24%. Multivariable Cox survival analysis in the weighted population showed a survival benefit over alternative treatments (PRFA vs LR: hazard ratio [HR], 1.41; 95% CI, 1.07-1.86; P = .01; TACE vs LR: HR, 1.86; 95% CI, 1.29-2.68; P = .001). Competing risk analysis confirmed a lower risk of cancer-related death in LR compared with PRFA and TACE. Conclusions and Relevance For patients with early multinodular HCC who are ineligible for transplant, LR should be prioritized as the ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38771633; info:eu-repo/semantics/altIdentifier/wos/WOS:001225477800002; volume:159; issue:8; journal:JAMA SURGERY; https://hdl.handle.net/11577/3539744 |
| DOI: |
10.1001/jamasurg.2024.1184 |
| Availability: |
https://hdl.handle.net/11577/3539744; https://doi.org/10.1001/jamasurg.2024.1184 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Accesso libero ; license uri:publisher |
| Accession Number: |
edsbas.F380ACE |
| Database: |
BASE |