| Title: |
Tolerability is more important than simplicity for treatment durability |
| Authors: |
Trottier, Benoit; Machouf, Nima; Huchet, Emmanuelle; Lavoie, Stephane; Vezina, Sylvie; Boissonnault, Michel; Charest, Louise; Munoz, Marie; Legault, Danielle; Longpré, Daniele; Thomas, Réjean |
| Source: |
Journal of the International AIDS Society ; volume 17, issue 4S3 ; ISSN 1758-2652 1758-2652 |
| Publisher Information: |
Wiley |
| Publication Year: |
2014 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Introduction Many studies have shown the superiority of single tablet regimens (STRs) of antiretrovirals for the treatment of HIV in terms of efficacy, adherence and rate of hospitalisation as they offer a low pill burden and once daily dosing. Our objective was to compare the duration of first‐line STRs to multi‐tablet regimens. Methods From our clinical database, we selected patients initiating any of the major first‐line regimens between 2007 and 2013. Two STRs, Atripla (ATP) and Complera (CPLR), were compared to three non‐STRs: two NRTIs and raltegravir (RAL), atazanavir/ritonavir (ATV/r) or darunavir/ritonavir (DRV/r). The primary outcome was time to discontinuation of the first‐line regimen. The association between regimen type and duration was estimated using Cox proportional hazards models adjusted for age, gender, baseline CD4, baseline viral load, risk factor, site and year of treatment initiation. Results A total of 743 patients (281 on STRs and 462 on non‐STRs) were included. 693 (93%) were male and median age was 43 years. Median length of follow‐up was 3.2 years. 56% of patients were MSM, 6% IDU and 6% from endemic countries. Patients on an STR were less likely to be IDU (p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.7448/ias.17.4.19765 |
| DOI: |
10.7448/IAS.17.4.19765 |
| Availability: |
https://doi.org/10.7448/ias.17.4.19765; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.7448%2FIAS.17.4.19765; https://onlinelibrary.wiley.com/doi/pdf/10.7448/IAS.17.4.19765 |
| Rights: |
http://creativecommons.org/licenses/by/3.0/ |
| Accession Number: |
edsbas.F3C13EB7 |
| Database: |
BASE |