| Title: |
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis |
| Authors: |
Zhang, Tao; Wahib, Ramez; Zazara, Dimitra E; Luecke, Joeran; Shiri, Ahmad Mustafa; Kempski, Jan; Zhao, Lilan; Agalioti, Theodora; Machicote, Andres Pablo; Giannou, Olympia; Belios, Ioannis; Jia, Rongrong; Zhang, Siwen; Tintelnot, Joseph; Seese, Hannes; Grass, Julia Kristin; Mercanoglu, Baris; Stern, Louisa; Scognamiglio, Pasquale; Fard-Aghaie, Mohammad; Seeger, Philipp; Wakker, Jonas; Kemper, Marius; Brunswig, Benjamin; Dupree, Anna; Lykoudis, Panagis M; Pikouli, Anastasia; Giorgakis, Emmanouil; Stringa, Pablo; Lausada, Natalia; Gentilini, Maria Virginia; Gondolesi, Gabriel E; Bachmann, Kai; Busch, Philipp; Grotelueschen, Rainer; Maroulis, Ioannis C; Arck, Petra C; Nakano, Ryosuke; Thomson, Angus W; Ghadban, Tarik; Tachezy, Michael; Melling, Nathaniel; Achilles, Eike-Gert; Puelles, Victor G; Nickel, Felix; Hackert, Thilo; Mann, Oliver; Izbicki, Jakob R; Li, Jun; Gagliani, Nicola; Huber, Samuel; Giannou, Anastasios D |
| Source: |
OncoImmunology , 12 (1) , Article 2269634. (2023) |
| Publisher Information: |
TAYLOR & FRANCIS INC |
| Publication Year: |
2023 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
IL-22; liver metastasis; Th22 |
| Description: |
Metastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10190711/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10190711/1/CD4%2B%20T%20cell-derived%20IL-22%20enhances%20liver%20metastasis%20by%20promoting%20angiogenesis.pdf; https://discovery.ucl.ac.uk/id/eprint/10190711/ |
| Rights: |
open |
| Accession Number: |
edsbas.F3C2112D |
| Database: |
BASE |