Prognostic scores for ursodeoxycholic acid-treated patients predict graft loss and mortality in recurrent primary biliary cholangitis after liver transplantation
| Title: | Prognostic scores for ursodeoxycholic acid-treated patients predict graft loss and mortality in recurrent primary biliary cholangitis after liver transplantation |
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| Authors: | Montano-Loza, Aldo J.; Lytvyak, Ellina; Hirschfield, Gideon; Hansen, Bettina E.; Ebadi, Maryam; Berney, Thierry; Toso, Christian; Magini, Giulia; Villamil, Alejandra; Nevens, Frederik; Van den Ende, Natalie; Pares, Albert; Ruiz, Pablo; Terrabuio, Débora; Trivedi, Palak J.; Abbas, Nadir; Donato, Maria Francesca; Yu, Lei; Landis, Charles; Dumortier, Jérôme; Dyson, Jessica Katharine; van der Meer, Adriaan J.; de Veer, Rozanne; Pedersen, Mark; Mayo, Marlyn; Manns, Michael P.; Taubert, Richard; Kirchner, Theresa; Belli, Luca S.; Mazzarelli, Chiara; Stirnimann, Guido; Floreani, Annarosa; Cazzagon, Nora; Russo, Francesco Paolo; Burra, Patrizia; Zigmound, Udi; Houri, Inbal; Carbone, Marco; Mulinacci, Giacomo; Fagiuoli, Stefano; Pratt, Daniel Stephan; Bonder, Alan; Schiano, Thomas D.; Haydel, Brandy; Lohse, Ansgar; Schramm, Christoph; Rüther, Darius; Casu, Stefania; Verhelst, Xavier; Beretta-Piccoli, Benedetta Terziroli; Robles, Mercedes; Corpechot, Christophe |
| Source: | Montano-Loza, A J, Lytvyak, E, the Global PBC Study Group, Hirschfield, G, Hansen, B E, Ebadi, M, Berney, T, Toso, C, Magini, G, Villamil, A, Nevens, F, Van den Ende, N, Pares, A, Ruiz, P, Terrabuio, D, Trivedi, P J, Abbas, N, Donato, M F, Yu, L, Landis, C, Dumortier, J, Dyson, J K, van der Meer, A J, de Veer, R, Pedersen, M, Mayo, M, Manns, M P, Taubert, R, Kirchner, T, Belli, L S, Mazzarelli, C, Stirnimann, G, Floreani, A, Cazzagon, N, Russo, F P, Burra, P, Zigmound, U, Houri, I, Carbone, M, Mulinacci, G, Fagiuoli, S, .... |
| Publication Year: | 2024 |
| Description: | Background & Aims: Recurrent primary biliary cholangitis (rPBC) develops in approximately 30% of patients and negatively impacts graft and overall patient survival after liver transplantation (LT). There is a lack of data regarding the response rate to ursodeoxycholic acid (UDCA) in rPBC. We evaluated a large, international, multi-center cohort to assess the performance of PBC scores in predicting the risk of graft and overall survival after LT in patients with rPBC. Methods: A total of 332 patients with rPBC after LT were evaluated from 28 centers across Europe, North and South America. The median age at the time of rPBC was 58.0 years [IQR 53.2–62.6], and 298 patients (90%) were female. The biochemical response was measured with serum levels of alkaline phosphatase (ALP) and bilirubin, and Paris-2, GLOBE and UK-PBC scores at 1 year after UDCA initiation. Results: During a median follow-up of 8.7 years [IQR 4.3–12.9] after rPBC diagnosis, 52 patients (16%) had graft loss and 103 (31%) died. After 1 year of UDCA initiation the histological stage at rPBC (hazard ratio [HR] 3.97, 95% CI 1.36-11.55, p = 0.01), use of prednisone (HR 3.18, 95% CI 1.04-9.73, p = 0.04), ALP xULN (HR 1.59, 95% CI 1.26-2.01, p |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 0168-8278; 1600-0641 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38821360; info:eu-repo/semantics/altIdentifier/pissn/0168-8278; info:eu-repo/semantics/altIdentifier/eissn/1600-0641 |
| DOI: | 10.1016/j.jhep.2024.05.010 |
| Availability: | https://pure.eur.nl/en/publications/e55c545e-7d76-4d1a-85f8-6415cdf57ba5; https://doi.org/10.1016/j.jhep.2024.05.010; https://pure.eur.nl/ws/files/167529792/Prognostic_scores_for_ursodeoxycholic_acid-treated_patients_predict_graft_loss_and_mortality_in_recurrent_primary_biliary_cholangitis_after_liver_transplantation.pdf; https://www.scopus.com/pages/publications/85197049913 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.F3CA94DC |
| Database: | BASE |