Efficacy of Levetiracetam and Phenobarbital as First-Line Treatment for Neonatal Seizures
| Title: | Efficacy of Levetiracetam and Phenobarbital as First-Line Treatment for Neonatal Seizures |
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| Authors: | Verwoerd, Carmen; Limjoco, Jamie; Rajamanickam, Victoria; Knox, Andrew |
| Source: | Journal of Child Neurology ; volume 37, issue 5, page 401-409 ; ISSN 0883-0738 1708-8283 |
| Publisher Information: | SAGE Publications |
| Publication Year: | 2022 |
| Description: | High neonatal seizure burden is associated with worsened neurodevelopmental outcomes. We compared the efficacy of initial treatment with levetiracetam vs phenobarbital for maintaining low seizure burden in a retrospective cohort of 25 neonates monitored with video electroencephalography (EEG). Video EEG tracing were reviewed and paired with medication bolus times to determine seizure burden after treatment. Initial cumulative dose of phenobarbital was 20 mg/kg in all but 1 case; initial cumulative dose of levetiracetam ranged from 50 to 100 mg/kg. Eleven of 17 (65%) patients sustained seizure burden |
| Document Type: | article in journal/newspaper |
| Language: | English |
| DOI: | 10.1177/08830738221086107 |
| Availability: | https://doi.org/10.1177/08830738221086107; https://journals.sagepub.com/doi/pdf/10.1177/08830738221086107; https://journals.sagepub.com/doi/full-xml/10.1177/08830738221086107 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Accession Number: | edsbas.F3D09D6 |
| Database: | BASE |