| Title: |
Momelotinib vs. ruxolitinib in myelofibrosis patient subgroups by baseline hemoglobin levels in the SIMPLIFY-1 trial |
| Authors: |
Gupta, V.; Oh, S.; Devos, T.; Dubruille, V.; Catalano, J.; Somervaille, Tim C P; Platzbecker, U.; Giraldo, P.; Kosugi, H.; Sacha, T.; Mayer, J.; Illes, A.; Ellis, C.; Wang, Z. H.; Carreras, F. J. G.; Strouse, B.; Mesa, R. |
| Contributors: |
The Christie NHS Foundation Trust & Cancer Research UK Manchester Institute, Manchester, UK. |
| Publication Year: |
2024 |
| Collection: |
The Christie School of Oncology: Christie Research Publications Repository |
| Description: |
A key hallmark of myelofibrosis is anemia, which ranges from mild to severe based on hemoglobin levels. To more clearly define outcomes with the Janus kinase (JAK) 1/JAK2/activin A receptor type 1 inhibitor momelotinib by anemia severity, we performed a descriptive post hoc exploratory analysis of the double-blind, randomized, phase 3 SIMPLIFY-1 study (NCT01969838; N = 432, JAK inhibitor naive, momelotinib vs. ruxolitinib); subgroups were defined by baseline hemoglobin: = 10 to = 12 g/dL (nonanemic). Spleen and symptom results were generally consistent with those previously reported for the intent-to-treat population. In anemic subgroups, momelotinib was associated with higher rates of transfusion independence and reduced/stable transfusion intensity vs. ruxolitinib. No new or unexpected safety signals were identified. Overall, momelotinib provides spleen, symptom, and anemia benefits to JAK inhibitor-naive patients with myelofibrosis regardless of baseline hemoglobin level, and greater anemia-related benefits vs. ruxolitinib in patients with hemoglobin |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://dx.doi.org/10.1080/10428194.2024.2328800; http://hdl.handle.net/10541/626928; Leukemia & Lymphoma |
| DOI: |
10.1080/10428194.2024.2328800 |
| Availability: |
http://hdl.handle.net/10541/626928; https://doi.org/10.1080/10428194.2024.2328800 |
| Accession Number: |
edsbas.F3E2DA76 |
| Database: |
BASE |