| Title: |
The dorsal aortic compartment is a developmental source of brown adipose tissue in mice |
| Authors: |
Heider, Sophie; Fischer, Cornelius; Secener, Ali Kerim; Vallecillo-Garcı́a, Pedro; Kotsaris, Georgios; Meisen, Zarah G.; Pawolski, Verena; Giesecke-Thiel, Claudia; Conrad, Thomas; Schulz, Tim J.; Sauer, Sascha; Stricker, Sigmar |
| Publication Year: |
2026 |
| Collection: |
FU Berlin: Refubium |
| Subject Terms: |
Differentiation; Multipotent stem cells; Musculoskeletal development; ddc:570 |
| Description: |
White adipose tissue primarily stores energy while brown adipose tissue dissipates energy as heat, holding promise for therapeutic use. Brown adipose tissue in the anterior trunk is believed to derive from the somitic mesoderm, although some depots are of partially unknown origin. Here we show that the subscapular, lateral, cervical and peri-aortic brown adipose depots, but not the interscapular depot, are in part formed by a non-somitic source. Single-cell sequencing along with genetic lineage tracing indicates that at embryonic day 9.5 the dorsal aorta compartment harbors multipotent mesenchymal progenitors expressing the transcription factor Osr1. Spreading laterally from the dorsal aortic midline, these cells contribute to adipose, cartilage and myogenic lineages. This study uncovers an alternative source of brown adipose tissue and suggests that a fraction of dorsal aorta-associated mesenchymal Osr1 + cells may represent the in vivo correlate of a multipotent progenitor cell type so far only characterized in vitro, the mesoangioblast. |
| Document Type: |
article in journal/newspaper |
| File Description: |
16 Seiten; application/pdf |
| Language: |
English |
| DOI: |
10.17169/refubium-50770 |
| DOI: |
10.1038/s41467-025-68147-9 |
| Availability: |
https://refubium.fu-berlin.de/handle/fub188/51043; https://doi.org/10.17169/refubium-50770; https://doi.org/10.1038/s41467-025-68147-9 |
| Rights: |
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.F418D54F |
| Database: |
BASE |