| Title: |
Ezetimibe Effectively Reduces Plasma Plant Sterols in Patients With Sitosterolemia |
| Authors: |
Salen, G.; von Bergmann, K.; Lütjohann, D.; Kwiterovich, P.; Kane, J.; Patel, S.B.; Musliner, T.; Stein, P.; Musser, B. |
| Source: |
Circulation ; volume 109, issue 8, page 966-971 ; ISSN 0009-7322 1524-4539 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2004 |
| Description: |
Background— Sitosterolemia is a recessively inherited disorder that results from mutations in either ABCG5 or G8 proteins, with hyperabsorption of dietary sterols and decreased hepatic excretion of plant sterols and cholesterol. As a consequence of markedly elevated plasma and tissue sitosterol and campesterol levels, premature atherosclerosis develops. Methods and Results— In this multicenter, double-blind, randomized, placebo-controlled study, we examined whether treatment with ezetimibe, an inhibitor of cholesterol absorption, reduces plant sterol levels in patients with sitosterolemia. After a 3-week placebo run-in, 37 patients were randomized to receive placebo (n=7) or ezetimibe 10 mg/d (n=30) for 8 weeks. Sitosterol concentrations decreased by 21% ( P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/01.cir.0000116766.31036.03 |
| DOI: |
10.1161/01.CIR.0000116766.31036.03 |
| Availability: |
https://doi.org/10.1161/01.cir.0000116766.31036.03; https://www.ahajournals.org/doi/full/10.1161/01.CIR.0000116766.31036.03 |
| Accession Number: |
edsbas.F457ED7D |
| Database: |
BASE |