| Title: |
An enquiry to the role of CB1 receptors in neurodegeneration |
| Authors: |
Fernandez-Moncada, Ignacio; Eraso-Pichot, Abel; Dalla Tor, Tommaso; Fortunato-Marsol, Berenice; Marsicano, Giovanni |
| Contributors: |
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB); Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM); H2020 European Research Council; Fondation pour la Recherche Médicale; Conseil Régional Aquitaine; ANR-18-CE16-0001,CaCoVi,Recepteurs aux cannabinoides dans le codage visuel cortical(2018); ANR-18-CE14-0029,MitObesity,Rôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité.(2018); ANR-21-NEU2-0001,CANSHANK,Involvement of the insula in the Autism neurodevelopmental disorder(2021); ANR-19-CE14-0039,MitoCB1-Fat,Role du recepteur CB1 mitocondriel du tissue adipeux dans la regulation de la balance energetique(2019); European Project: 640923,ERC-2014-PoC,ERC-2014-PoC,CannaPreg(2015); European Project: 260515,ERC-2010-StG_20091118,ERC-2010-StG_20091118,ENDOFOOD(2011) |
| Source: |
ISSN: 0969-9961. |
| Publisher Information: |
CCSD; Elsevier |
| Publication Year: |
2023 |
| Subject Terms: |
Huntington; Parkinson; Cannabinoids; CB1 receptor; Alzheimer; [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] |
| Description: |
International audience ; Neurodegenerative disorders are debilitating conditions that impair patient quality of life and that represent heavy social-economic burdens to society. Whereas the root of some of these brain illnesses lies in autosomal inheritance, the origin of most of these neuropathologies is scantly understood. Similarly, the cellular and molecular substrates explaining the progressive loss of brain functions remains to be fully described too. Indeed, the study of brain neurodegeneration has resulted in a complex picture, composed of a myriad of altered processes that include broken brain bioenergetics, widespread neuroinflammation and aberrant activity of signaling pathways. In this context, several lines of research have shown that the endocannabinoid system (ECS) and its main signaling hub, the type-1 cannabinoid (CB1) receptor are altered in diverse neurodegenerative disorders. However, some of these data are conflictive or poorly described. In this review, we summarize the findings about the alterations in ECS and CB1 receptors signaling in three representative brain illnesses, the Alzheimer's, Parkinson's and Huntington's diseases, and we discuss the relevance of these studies in understanding neurodegeneration development and progression, with a special focus on astrocyte function. Noteworthy, the analysis of ECS defects in neurodegeneration warrant much more studies, as our conceptual understanding of ECS function has evolved quickly in the last years, which now include glia cells and the subcellular-specific CB1 receptors signaling as critical players of brain functions. © 2023 |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/grantAgreement//640923/EU/Development of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for the treatment of schizophrenia and psychotic syndromes/CannaPreg; info:eu-repo/grantAgreement//260515/EU/Neurocircuitry of endocannabinoid regulation of food intake/ENDOFOOD |
| DOI: |
10.1016/j.nbd.2023.106235 |
| Availability: |
https://hal.science/hal-04488088; https://hal.science/hal-04488088v1/document; https://hal.science/hal-04488088v1/file/MAGENDIE_NeurobiolDis_2023_Fern%C3%A1ndezMoncada.pdf; https://doi.org/10.1016/j.nbd.2023.106235 |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.F4679B49 |
| Database: |
BASE |