| Title: |
Lab methods, progression & risk factors for CKD - 2 |
| Authors: |
Zhang, Minmin; Chen, Jing; Liu, Shaojun; You, Li; Lin, Shanyan; Hao, Chuanming; Gu, Yong; Meijer, Esther; Bakker, Stephan J.L.; Halbesma, Nynke; de Jong, Paul E.; Struck, Joachim; Gansevoort, Ron T.; Minakuchi, Hitoshi; Wakino, Shu; Sueyasu, Keiko; Hasegawa, Kazuhiro; Hara, Yoshikazu; Yoshioka, Kyoko; Washida, Naoki; Tatematsu, Satoru; Tokuyama, Hirofumi; Hayashi, Koichi; Itoh, Hiroshi; Hojs, Radovan; Bevc, Sebastjan; Ekart, Robert; Gorenjak, Maksimiljan; Puklavec, Ludvik; Inoue, Tsutomu; Kozawa, Eito; Kikuta, Tomohiro; Sato, Takahiko; Tsuda, Masahiro; Arai, Jonde; Watanabe, Shinichi; Watanabe, Yusuke; Kobayashi, Kazuhiro; Ikeda, Naofumi; Tanaka, Jyunji; Suzuki, Hiromichi; Ibrini, J.; Darwish, S.; Chana, R.S.; Johnson, T.; Brunskill, N.; El Nahas, A.M.; Shaarawy, Abdel-Bassit; El-Ghandor, Ahmed; El-Kheshen, Jamal; Brunori, Giuliano; Borghetti, Francesca; Sottini, Laura; Scalone, Luciana; Viola, Battista; Brancati, Barbara; Mantovani, Lorenzo; Cancarini, Giovanni; Waldum, Baard; Westheim, Arne; Grundtvig, Morten; Hole, Torstein; Gullestad, Lars; Os, Ingrid; Hall, Matthew; Al-Jayyousi, Reem; Ferraro, Alastair; Lightstone, Liz; Lipkin, Graham; Mihaescu, Adelina; Noguiera, Estela; Sinammon, Kim; Tullett, Karen; Brunskill, Nigel; Carr, Sue; Sirvent, Ana Esther; González, Cesar; Enríquez, Ricardo; Fernández, Francisco Javier; Millán, Isabel; Barber, Xavier; Amorós, Francisco; García, Julián; Reyes, Adolfo; Qunibi, Wajeh; Abdellatif, Abdul; Cadena, Andres; Sankar, Sudheer; Gelfond, Jonathan; Chen, Zhao-Hong; Zhang, Jiong; Qin, Wei-Song; Hong, Yi-Mei; Zhang, Wen; Li, Lei-Shi; Liu, Zhi-Hong; Muroya, Yoshikazu; Ito, Osamu; Takashima, Kenta; Cao, Peng-yu; Ito, Daisuke; Kanazawa, Masayuki; Kohzuki, Masahiro; Sun, Qiaolin; Chen, Yipu; Rui, Hongliang; Yanagisawa, Naoki; Ando, Minoru; Ajisawa, Atsushi; Imamura, Akifumi; Suganuma, Akihiko; Tsuchiya, Ken; Nitta, Kosaku; Krikken, Jan; Waanders, Femke; Dallinga-Thie, Geesje; Dikkeschei, Bert; Vogt, Liffert; Navis, Gerjan; Dullaart, Robin; Taki, Fumika; Futatsuyama, Miyuki; Tsugawa, Yusuke; Nishizaki, Yuji; Kaneshiro, Yuki; Tamagaki, Keiichi; Kasori, Ryoko; Komatsu, Yasuhiro; Mircescu, G.; Stancu, S.; Zugravu, A.; Stanciu, A.; Barsan, L.; Lipan, M.; Dumitru, D.; Collins, John; Hotu, Cheri; Gamble, Greg; Bagg, Warwick; Braatvedt, Geoff; Lin, Xiaojie; Ding, Jiaxiang; Zhu, Li; Zhao, Minghui; Zhang, Hong; Nerlander, Maximilian; Voong, Kieren; Manghat, Padmini; Hampson, Geeta; Harrington, Domonic; Shearer, Martin; Goldsmith, David; Bacallao Méndez, Raymed; Mañalich, Reynaldo; Bikbov, Boris; Vázquez, María E.; Gaspari, Flavio; Perico, Norberto; Remuzzi, Giuseppe; Wu, Yu; Su, Tao; Wei, Hong; Li, XiaoMei; Volkmann, Mathias Alexandre; Burmeister, Jayme E.; Behr, Paulo E.; Kalil, Renato A.K.; Nesralla, Ivo A.; Santanna, Joao R.M.; Prates, Paulo R.; Scorsato, Caroline B.; Miotto, Ramses; Schuster, Leon; Praditpornsilpa, Kearkiat; Townamchai, Natavudh; Chawatanarat, Tawatchai; Tiranathanagul, Khajohn; Katawatin, Pisut; Trakarnvanich, Thananda; Kanjanabuch, Talerngsak; Avihingsanon, Yingyos; Tungsanga, Kriang; Eiam-Ong, Somchai; Convento, Marcia Bastos; Pessoa, Edson Andrade; Borges, Fernanda Teixeira; Schor, Nestor; Kosmadakis, George; Bevington, Alan; Smith, Alice C.; Viana, Joao L.; Clapp, Emma L.; Bishop, Nicolette C.; Feehally, John; Loriga, Giacomina; Farre, Giovanna; Scanu, Bastianina; Pisanu, Elisabetta; Sanna, Manuela; Satta, Andrea; Martin del Campo, Fabiola; Batis, Carolina; Ordaz, Susan; Cortes, Laura; da Silvera, Ruth; Martinez, Hector; Cueto-Manzano, Alfonso; Koch, B.C.; van der Putten, K.; Nagtegaal, J.E.; Wielders, J.P.; van Someren, E.J.; ter Wee, P.M.; Gaillard, C.A.; Sigrist, Mhairi; Lim, Linda; Levin, Adeera; Kretowicz, Marek; Goszka, Grazyna; Johnson, Richard; Manitius, Jacek; Sotila, Gianina; Tuta, Liliana; Sburlan, A.; Chalapipat, Oran; Disthabanchong, Sinee; Kurathong, Sathit; Stitchantrakul, Wasana; Chailurkit, La-Or; Okamoto, Chinatsu; Koizumi, Mitsuteru; Ohno, Shoko; Koga, Ken-ichi; Kikuchi, Yuko; Seta, Koichi; Yahata, Kensei; Sugawara, Akira; Consoni, Paulo R.; Sant'Anna, João R.M.; Prakash, Anupam; Singh, Narinder Pal; Kalra, Kanika; Kaur, Gurmeen; Toteja, G.S.; White, Michel; Boucher, Anne; Lord, Helene; Pelletier, Guy B.; Racine, Normand; Dandavino, Raymond; Senecal, Lynne; Cossette, Marieve; Carrier, Michel; Collette, Suzon; Avdelidou, Aphrodite; Mallindretos, Pavlos; Raptis, Vasilios; Makedou, Kali; Sioulis, Athanasios; Hitoglou-Makedou, Areti; Kapoulas, Stergios; Grekas, Dimitrios; McIntyre, Natasha; Fluck, Richard; McIntyre, Christopher; Taal, Maarten; Lu, Yi-Zhou; Zeng, Cai-Hong; Bosch, Elvira; Garcia-Cantón, Cesar; Ramirez, Ana; Rossique, Pilar; Culebras, Carlos; Cubas, Javiel; Glücksman, Constanza; Auyanet, Ingrid; Toledo, Agustin; Lago, Mar; Checa, Dolores; Qian, Ying; Wang, Zhaohui; Li, Xiao; Chen, Nan; Reinhard, Mark; Erlandsen, Erland J.; Randers, Else; Barrio, Vicente; Fernandez Juarez, Gema; Corchete, Elena; Mitjavila, Mercedes; Gorgojo, Juan Jose; Loekman, Jodi; Widiana, Raka; Suwitra, Ketut; Chiarelli, Giusy; Weber, Catherine; Romann, Alexandria; Garcia-Canton, Cesar; Cabrera, Leonardo; Gerra, Rita; Fuentes, Rafael; Fassett, Robert; Robertson, Iain; Ball, Madeleine; Geraghty, Dominic; Sharman, James; Coombes, Jeff; Lezaic, Visnja; Bajcetic, Sanja; Perunicic-Pekovic, Gordana; Bukvic, Danica; Dimkovic, Nada; Djukanovic, Ljubica; Kirsanova, Tatyna; Kozlovskaya, Natalya; Platova, Elena; Sadovnikov, Vladimir; Shachnova, Elena; Belyaeva, Larisa; Kushnir, Vera; Koroshi, Alketa; Hoxha, Benereta; Emrullai, Etleva; Thereska, Nestor; Marques, Luiz Paulo José; Rocco, Regina; Carvalho, Ana Luiza; Novaes, Benedita C.; Victor, Maria Helena; Santos, Omar R.; Salmayer, Alexander; Piminova, Tatiana; Reznik, Yana; Likstanov, Mikhail; Lutsenko, Oksana; Semina, Svetlana; Chesnokova, Liudmila |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2010 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Sunday |
| Description: |
INTRODUCTION AND AIMS: Aldosterone is reported to promote fibrosis of multiple organs. Besides the basic role of the pHi and volume regulation of the cell, many studies suggested that Na+-H+exchange isoform 1 (NHE1) has also been shown to play an important role in cell proliferation and fibrosis. Our previous study has demonstrated that aldosterone can activate NHE1 and increase its expression in rat mesangial cells. The present study examined the role of NHE1 in aldosterone induced glomerulosclerosis in rats. METHODS: Sprague-dawley male rats were subjected 5/6 nephrectomy and divided into 4 groups: rats subjected to sham operation were used as control (SHAM group); 5/6 nephrectomy (SNX group); SNX treated with aldosterone via osmotic mini-pump (ALDO group) and SNX treated with aldosterone plus NHE1 antagonist 5-(N, N-Dimethyl) amiloride hydrochloride (DMA) (ALDO+DMA group). The rats were sacrificed at the 12th week. Proteinuria, renal function and artery blood pressure were measured. Glomerulosclerosis,tubulointerstitial fibrosis and tubular proteinaceous cast were evaluated under PAS or Masson staining. The expression of fibronectin, TGFβ1 and proliferating cell nuclear antigen(PCNA) was examined by immunohistochemistry and Western blot. RESULTS: Aldosterone treatment significantly increased systemic blood pressure compared with SNX rats (ALDO: 224±9.4 mmHg vs. SNX:194±6.36 mmHg, p |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://ckj.oxfordjournals.org/cgi/content/short/2/suppl_2/ii1677; http://dx.doi.org/10.1093/ndtplus/2.s2.23 |
| DOI: |
10.1093/ndtplus/2.s2.23 |
| Availability: |
http://ckj.oxfordjournals.org/cgi/content/short/2/suppl_2/ii1677; https://doi.org/10.1093/ndtplus/2.s2.23 |
| Rights: |
Copyright (C) 2010, European Renal Association - European Dialysis and Transplant Assoc |
| Accession Number: |
edsbas.F4776EA7 |
| Database: |
BASE |