| Title: |
Liver stiffness and histological features in healthy persons, and patients with occult hepatitis B, chronic active hepatitis B, and hepatitis B-related cirrhosis. |
| Authors: |
Fung, JYY; Lai, CL; Chan, SC; But, D; Seto, WKW; Cheng, CTK; Wong, DKH; Lo, CM; Fan, ST; Yuen, RMF |
| Publisher Information: |
//www.hepatology.org/; United States |
| Publication Year: |
2009 |
| Collection: |
University of Hong Kong: HKU Scholars Hub |
| Description: |
Background: Liver stiffness measurement using transient elas-tography has become a popular tool to assess liver fibrosis.Aim: To determine liver stiffness values and histological featuresin healthy subjects and patients with chronic hepatitis B.Patients and Methods: A total of 157 persons were included(28 healthy subjects, 18 occult hepatitis B infection, 102 activechronic hepatitis B, and 9 end-stage hepatitis B cirrhosis). His-tology and liver stiffness measurements were obtained from allpatients. Results: The median liver stiffness in healthy subjects,occult hepatitis B, active hepatitis B, and end-stage cirrhosiswere 4.6, 4.2, 8.7, and 33.8 kPa respectively, with signifi-cantly higher values in the latter 2 groups compared to the for-mer 2 groups (p11.0 kPa. The over-all AUROC for diagnosing cirrhosis using a cut-off of 11.3 kPawas 0.89. Conclusion: Liver stiffness measurement has an over-all good diagnostic accuracy with excellent negative predictivevalue. In chronic active hepatitis B, the diagnostic accuracymay be reduced when underlying inflammatory activity issevere. ; link_to_OA_fulltext |
| Document Type: |
conference object |
| Language: |
English |
| Relation: |
Hepatology; 979A; 181236; 4 suppl.; https://hub.hku.hk/handle/10722/224432; 50 |
| DOI: |
10.1002/hep.23306 |
| Availability: |
https://hub.hku.hk/handle/10722/224432; https://doi.org/10.1002/hep.23306 |
| Rights: |
Hepatology. Copyright © John Wiley & Sons, Inc. |
| Accession Number: |
edsbas.F4A23264 |
| Database: |
BASE |