| Title: |
Worldwide trends in the burden of asthma symptoms in school-aged children: Global Asthma Network Phase I cross-sectional study |
| Authors: |
Asher, MI; Rutter, CE; Bissell, K; Chiang, CY; El Sony, A; Ellwood, E; Ellwood, P; García-Marcos, L; Marks, GB; Morales, E; Mortimer, K; Pérez-Fernández, V; Robertson, S; Silverwood, RJ; Strachan, DP; Pearce, N; Masekela, R; Strachan, D; Martinez-Torres, A; Rutter, C; Silverwood, R; Mallol, J; Soto-Martínez, M; Cabrera Aguilar, A; Douros, K; Sabir, M; Singh, M; Singh, V; Sukumaran, TU; Awasthi, S; Kabra, SK; Salvi, S; García-Almaráz, R; Mérida-Palacio, JV; Del Río Navarro, BE; González-Díaz, SN; Navarrete-Rodriguez, EM; Sánchez, JF; Falade, AG; Zar, HJ; López-Silvarrey Varela, A; González Díaz, C; Nour, M; Dib, G; Mohammad, Y; Huang, JL; Chinratanapisit, S; Soto-Quirós, ME; Vichyanond, P; Aguilar, P; Barba, S; Kumar, L; Sharma, SK; Linares-Zapién, FJ; Onadeko, BO; Musa, OAA; Aguirre, V; Baeza-Bacab, M; Mohammad, S; Cortez, E; Gratziou, CH; Chopra, K; Hanumante, NM; Nelson, H; Rubio, AD; Hsieh, KH; Shah, J |
| Source: |
The Lancet , 398 (10311) pp. 1569-1580. (2021) |
| Publication Year: |
2021 |
| Collection: |
University College London: UCL Discovery |
| Description: |
Background: Asthma is the most common chronic disease in children globally. The Global Asthma Network (GAN) Phase I study aimed to determine if the worldwide burden of asthma symptoms is changing. Methods: This updated cross-sectional study used the same methods as the International study of Asthma and Allergies in Childhood (ISAAC) Phase III. Asthma symptoms were assessed from centres that completed GAN Phase I and ISAAC Phase I (1993–95), ISAAC Phase III (2001–03), or both. We included individuals from two age groups (children aged 6–7 years and adolescents aged 13–14 years) who self-completed written questionnaires at school. We estimated the 10-year rate of change in prevalence of current wheeze, severe asthma symptoms, ever having asthma, exercise wheeze, and night cough (defined by core questions in the questionnaire) for each centre, and we estimated trends across world regions and income levels using mixed-effects linear regression models with region and country income level as confounders. Findings: Overall, 119 795 participants from 27 centres in 14 countries were included: 74 361 adolescents (response rate 90%) and 45 434 children (response rate 79%). About one in ten individuals of both age groups had wheeze in the preceding year, of whom almost half had severe symptoms. Most centres showed a change in prevalence of 2 SE or more between ISAAC Phase III to GAN Phase I. Over the 27-year period (1993–2020), adolescents showed a significant decrease in percentage point prevalence per decade in severe asthma symptoms (–0·37, 95% CI –0·69 to –0·04) and an increase in ever having asthma (1·25, 0·67 to 1·83) and night cough (4·25, 3·06 to 5·44), which was also found in children (3·21, 1·80 to 4·62). The prevalence of current wheeze decreased in low-income countries (–1·37, –2·47 to –0·27], in children and –1·67, –2·70 to –0·64, in adolescents) and increased in lower-middle-income countries (1·99, 0·33 to 3·66, in children and 1·69, 0·13 to 3·25, in adolescents), but it was stable in upper-middle-income and ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10138110/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10138110/1/1-s2.0-S0140673621014501-main.pdf; https://discovery.ucl.ac.uk/id/eprint/10138110/ |
| Rights: |
open |
| Accession Number: |
edsbas.F4C6D47 |
| Database: |
BASE |