| Title: |
Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy |
| Authors: |
Jacobs, Jana L; Haidar, Ghady; Naqvi, Asma; McCormick, Kevin D; Sobolewski, Michele; Treat, Benjamin R; Heaps, Amy L; Simpson, Jordan; Kramer, Kailey Hughes; McCreary, Erin; Bariola, J Ryan; Klamar-Blain, Cynthia; Macatangay, Bernard J C; Dimitrov, Dimiter; Li, Wei; Marino, Christopher C; Raptis, Anastasios; Sethi, Rahil; Chandran, Uma; Barratt-Boyes, Simon; Parikh, Urvi M; Mellors, John W |
| Contributors: |
National Institutes of Health; (NIH) |
| Source: |
Open Forum Infectious Diseases ; volume 10, issue 5 ; ISSN 2328-8957 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2023 |
| Description: |
Prolonged coronavirus disease 2019 may generate new viral variants. We report an immunocompromised patient treated with monoclonal antibodies who experienced rebound of viral RNA and emergence of an antibody-resistant (>1000-fold) variant containing 5 mutations in the spike gene. The mutant virus was isolated from respiratory secretions, suggesting the potential for secondary transmission. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ofid/ofad278 |
| DOI: |
10.1093/ofid/ofad278/50367049/ofad278.pdf |
| Availability: |
https://doi.org/10.1093/ofid/ofad278; https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad278/50367049/ofad278.pdf; https://academic.oup.com/ofid/article-pdf/10/5/ofad278/50493142/ofad278.pdf |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.F4D4FAF4 |
| Database: |
BASE |