| Title: |
Global, regional, and national burden of pulmonary arterial hypertension, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021 |
| Authors: |
Leary, Peter J.; Lindstrom, Megan; Johnson, Catherine O.; Emmons-Bell, Sophia; Rich, Stuart; Corris, Paul A.; DuBrock, Hilary M.; Ventetuolo, Corey E.; Abate, Yohannes Habtegiorgis; Abdelmasseh, Michael; Aboagye, Richard Gyan; Abualruz, Hasan; Abu-Gharbieh, Eman; Aburuz, Salahdein; Adamu, Lawan Hassan; Adao, Rui; Addo, Isaac Yeboah; Adedoyin, Rufus Adesoji; Adetunji, Juliana Bunmi; Adzigbli, Leticia Akua; Ahinkorah, Bright Opoku; Ahmad, Firdos; Ahmadzade, Amir Mahmoud; Ahmed, Ayman; Ahmed, Haroon; Ahmed, Syed Anees; Akhlaghi, Shiva; Akkaif, Mohammed Ahmed; Al Awaidy, Salah; Alalalmeh, Samer O.; Albakri, Almaza; Aldawsari, Khalifah A.; Almahmeed, Wael; Alshahrani, Najim Z.; Altaf, Awais; Aly, Hany; Alzoubi, Karem H.; Al-Zyoud, Walid Adnan; Amani, Reza; Amusa, Ganiyu Adeniyi; Andrei, Catalina Liliana; Anwar, Saleha; Anyasodor, Anayochukwu Edward; Aravkin, Aleksandr Y.; Areda, Demelash; Asmerom, Haftu Asmerom; Aujayeb, Avinash; Azzam, Ahmed Y.; Babu, Abraham Samuel; Bagherieh, Sara; Baltatu, Ovidiu Constantin; Barqawi, Hiba Jawdat; Bastan, Mohammad-Mahdi; Batra, Kavita; Bayleyegn, Nebiyou Simegnew; Behnoush, Amir Hossein; Bhalla, Jaideep Singh; Bhaskar, Sonu; Bhat, Vivek; Bitaraf, Saeid; Bitra, Veera R.; Boloor, Archith; Braithwaite, Dejana; Brauer, Michael; Bulto, Lemma N.; Bustanji, Yasser; Chattu, Vijay Kumar; Chi, Gerald; Chichagi, Fatemeh; Chong, Bryan; Chowdhury, Rajiv; Cindi, Zinhle; Cruz-Martins, Natalia; Dadana, Sriharsha; Dadras, Omid; Dahiru, Tukur; Dai, Xiaochen; Dashtkoohi, Mohadese; DeAngelo, Sean; Debopadhaya, Shayom; Demessa, Berecha Hundessa; Desai, Hardik Dineshbhai; Dhulipala, Vishal R.; Diaz, Michael J.; Diress, Mengistie; Thanh, Chi Do; Thao, Huynh Phuong Do; Khanh, Duy Doan; dos Santos, Wendel Mombaque; Doshi, Rajkumar Prakashbhai; Dowou, Robert Kokou; Dziedzic, Arkadiusz Marian; Elhadi, Muhammed; Etaee, Farshid; Fabin, Natalia; Fagbamigbe, Adeniyi Francis; Faris, Pawan Sirwan; Feyisa, Bikila Regassa; Rodrigues, Celia Fortuna; Gandhi, Aravind P.; Ganiyani, Mohammad Arfat; Gela, Yibeltal Yismaw; Getie, Molla; Jolfayi, Amir Ghaffari; Ghasemzadeh, Afsaneh; Goldust, Mohamad; Golechha, Mahaveer; Guan, Shi-Yang; Gudeta, Mesay Dechasa; Gupta, Mohak; Gupta, Rahul; Hadei, Mostafa; Hammoud, Ahmad; Hasnain, Md Saquib; Tabatabaei, Mahgol Sadat Hassan Zadeh; Hay, Simon I.; Hegazi, Omar E.; Hemmati, Mehdi; Hiraike, Yuta; Nguyen, Quoc Hoan; Hultstrom, Michael; Huynh, Hong-Han; Ibitoye, Segun Emmanuel; Ilesanmi, Olayinka Stephen; Ismail, Nahlah Elkudssiah; Iwu, Chidozie Declan; Jaggi, Khushleen; Jain, Akhil; Jakovljevic, Mihajlo; Jee, Sun Ha; Jeswani, Bijay Mukesh; Jha, Anil K.; Jokar, Mohammad; Joseph, Nitin; Jozwiak, Jacek Jerzy; Kabir, Hannaneh; Kahe, Farima; Kamireddy, Arun; Kanmanthareddy, Arun R.; Karimi, Hanie; Behnagh, Arman Karimi; Kazemian, Sina; Keshavarz, Pedram; Khalaji, Amirmohammad; Khan, Mohammad Jobair; Khidri, Feriha Fatima; Kim, Min Seo; Kondlahalli, Shivakumar K.M. Marulasiddaiah; Kothari, Nikhil; Krishan, Kewal; Kulimbet, Mukhtar; Kumar, Ashish; Latifinaibin, Kaveh; Thao, Thi Thu Le; Ledda, Caterina; Lee, Seung Won; Li, Ming-Chieh; Lim, Stephen S.; Liu, Shuke; Mahmoudi, Elham; Makram, Omar M.; Malhotra, Kashish; Malik, Ahmad Azam; Malta, Deborah Carvalho; Manla, Yosef; Martorell, Miquel; Mehrabani-Zeinabad, Kamran; Merati, Mohsen; Mestrovic, Tomislav; Mirdamadi, Niloofar; Misra, Arup Kumar; Mokdad, Ali H.; Moni, Mohammad Ali; Ghalibaf, AmirAli Moodi; Moraga, Paula; Morovatdar, Negar; Motappa, Rohith; Mousavi-Aghdas, Seyed Ali; Mustafa, Ahmad; Naik, Ganesh R.; Najafi, Mohammad Sadeq; Najdaghi, Soroush; Nanavaty, Dhairya P.; Davani, Delaram Narimani; Natto, Zuhair S.; Nauman, Javaid; Nguyen, Dang H.; Phat, Tuan Nguyen; Niazi, Robina Khan; Oancea, Bogdan; Olanipekun, Titilope O.; Oliveira, Glaucia Maria Moraes; Omar, Hany A.; Padukudru, Mahesh P.A.; Pan, Feng; Pandi-Perumal, Seithikurippu R.; Pantazopoulos, Ioannis; Parikh, Romil R.; Petcu, Ionela-Roxana; Hoang, Nhat Pham; Hoang, Tran Pham; Philip, Anil K.; Prates, Elton Junio Sady; Puvvula, Jagadeesh; Qian, Gangzhen; Rafferty, Quinn; Rahim, Fakher; Rahimi, Mehran; Rahman, Mosiur; Rahman, Muhammad Aziz; Rahmanian, Mohammad; Rahmanian, Nazanin; Rahmati, Masoud; Rahmati, Rahem; Ramadan, Mahmoud Mohammed; Ramphul, Kamleshun; Rana, Juwel; Rao, Indu Ramachandra; Rashedi, Sina; Ravikumar, Nakul; Rawaf, Salman; Ray, Ayita; Reddy, Murali Mohan Rama Krishna; Redwan, Elrashdy Moustafa Mohamed; Roy, Negar Rezaei Priyanka; Saad, Aly M.A.; Saddik, Basema Ahmad; Sadeghi, Masoumeh; Saeb, Mohammad Reza; Sharif-Askari, Fatemeh Saheb; Sharif-Askari, Narjes Saheb; Saleh, Mohamed A.; Sani, Najib Yahaya; Saraswati, Ushasi; Saravanan, Aswini; Saulam, Jennifer; Schuermans, Art; Schumacher, Austin E.; Semagn, Birhan Ewunu; Sethi, Yashendra; Seylani, Allen; Shafeghat, Melika; Shahwan, Moyad Jamal; Shamim, Muhammad Aaqib; Shamsi, Anas; Sharfaei, Sadaf; Sharma, Kamal; Sharma, Nitish; Sherif, Akil Adrian; Shiue, Ivy; Shorofi, Seyed Afshin; Siddig, Emmanuel Edwar; Singh, Harpreet; Singh, Jasvinder A.; Singh, Paramdeep; Singh, Surjit; Sobia, Farrukh; Solanki, Ranjan; Solanki, Shipra; Spartalis, Michael; Swain, Chandan Kumar; Szarpak, Lukasz; Tabatabaei, Seyyed Mohammad; Tabche, Celine; Tamuzi, Jacques Lukenze; Tan, Ker-Kan; Teramoto, Masayuki; Tharwat, Samar; Thienemann, Friedrich; Thien, Tan Tri Tai Truyen; Tsegay, Guesh Mebrahtom; Udoakang, Aniefiok John; Van den Eynde, Jef; Varthya, Shoban Babu; Verma, Madhur; Vervoort, Dominique; Vinayak, Manish; Viskadourou, Maria; Wang, Fang; Wickramasinghe, Nuwan Darshana; Wilandika, Angga; Xu, Suowen; Yu, Chuanhua; Zare, Iman; Zeineddine, Mohammad A.; Zhang, Zhi-Jiang; Zhu, Lei; Zhumagaliuly, Abzal; Zielinska, Magdalena; Zyoud, Samer H.; Murray, Christopher J.L.; Roth, Gregory A. |
| Source: |
ISSN:2213-2600 ; ISSN:2213-2619 ; Lancet Respiratory Medicine, vol. 13 (1), (69-79. |
| Publisher Information: |
Elsevier |
| Publication Year: |
2025 |
| Subject Terms: |
Science & Technology; Life Sciences & Biomedicine; Critical Care Medicine; Respiratory System; General & Internal Medicine; UNITED-STATES; PREVALENCE; REGISTRY; Humans; Global Burden of Disease; Female; Male; Middle Aged; Aged; Adult; Pulmonary Arterial Hypertension; Adolescent; Young Adult; Global Health; Child; 80 and over; Preschool; Hypertension; Pulmonary; Risk Factors; Infant; GBD 2021 Pulmonary Arterial Hypertension Collaborators; 1103 Clinical Sciences; 1117 Public Health and Health Services; 1199 Other Medical and Health Sciences |
| Description: |
BACKGROUND: Pulmonary arterial hypertension (PAH) is a vascular disease characterised by restricted flow and high pressure through the pulmonary arteries, leading to progressive right heart failure and death. This study reports the global burden of PAH, leveraging all available data and using methodology of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) to understand the epidemiology of this under-researched and morbid disease. METHODS: Prior to the current effort, the burden of PAH was included in GBD as a non-specific contributor to "other cardiovascular and circulatory disease" burden. In this study, PAH was distinguished as its own cause of death and disability in GBD, producing comparable and consistent estimates of PAH burden. We used epidemiological and vital registry data to estimate the non-fatal and fatal burden of PAH in 204 countries and territories from 1990 to 2021 using standard GBD modelling approaches. We specifically focused on PAH (group 1 pulmonary hypertension), and did not include pulmonary hypertension groups 2-5. FINDINGS: In 2021, there were an estimated 192 000 (95% uncertainty interval [UI] 155 000-236 000) prevalent cases of PAH globally. Of these, 119 000 (95 900-146 000) were in females (62%) and 73 100 (58 900-89 600) in males (38%). The age-standardised prevalence was 2·28 cases per 100 000 population (95% UI 1·85-2·80). Prevalence increased with age such that the highest prevalence was among individuals aged 75-79 years. In 2021, there were 22 000 deaths (18 200-25 400) attributed to PAH globally, with an age-standardised mortality rate of 0·27 deaths from PAH per 100 000 population (0·23-0·32). The burden of disease appears to be improving over time (38·2% improvement in age-standardised years of life lost [YLLs] in 2021 relative to 1990). YLLs attributed to PAH were similar to estimates for conditions such as chronic myeloid leukaemia, multiple sclerosis, and Crohn's disease. INTERPRETATION: PAH is a rare but fatal disease that accounts for a considerable ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://lirias.kuleuven.be/handle/20.500.12942/774490; https://pubmed.ncbi.nlm.nih.gov/39433052 |
| DOI: |
10.1016/S2213-2600(24)00295-9 |
| Availability: |
https://lirias.kuleuven.be/handle/20.500.12942/774490; https://hdl.handle.net/20.500.12942/774490; https://lirias.kuleuven.be/retrieve/849a7bdc-bbca-45cb-869a-756dfb1712ea; https://doi.org/10.1016/S2213-2600(24)00295-9; https://pubmed.ncbi.nlm.nih.gov/39433052 |
| Rights: |
info:eu-repo/semantics/openAccess ; public ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.F4E8B2F6 |
| Database: |
BASE |