| Title: |
The impact of diabetes mellitus on foot perfusion pre- and post-revascularisation measured by near-infrared fluorescence imaging |
| Authors: |
Koning, Stefan; Peul, Roderick C.; Kruiswijk, Mo W.; Tange, Floris P.; Schaik, Jan van; Schepers, Abbey; Brouwers, Jeroen J.W.M.; Rijswijk, Carla S.P.; Bogt, Koen E.A.; Eiberg, Jonas P.; Vahrmeijer, Alexander L.; Hamming, Jaap F.; Hoven, Pim van den; Vorst, Joost R. van der |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2025 |
| Description: |
Introduction: Diabetes Mellitus (DM) contributes to the complexity of lower extremity arterial disease (LEAD), inducing peripheral neuropathy and increasing susceptibility to severe ischemia, foot ulceration, and amputation. Perfusion differences in LEAD patients with and without DM may advocate a more individualised revascularisation strategy than the current WIfI classification for risk prediction. This study aims to utilise near-infrared (NIR) fluorescence imaging with Indocyanine Green (ICG) to assess perfusion parameters before and after revascularisation in DM and non-DM patients and explore their relationship with clinical outcome. Methods ICG NIR fluorescence imaging was performed pre- and post-revascularisation in LEAD patients with and without DM. Three time-related perfusion parameters were analysed to assess differences in perfusion patterns. Clinical improvement (CI) after revascularisation was analysed in chronic limb-threatening ischemia (CLTI) patients with- and without DM. Results Successful revascularisation and ICG NIR fluorescence measurements were conducted in 128 patients (144 limbs), with 42 (48 limbs) DM patients. Two out of three revascularisation parameters post-operatively improved significantly in the DM group, compared to three out of three in the non-DM group. Additionally, in the sub-analyses of the CLTI group, no parameters in the DM CI group showed significant enhancement, compared to significant improvements in all parameters in the non-DM CI group (p = 0.003 - |
| Document Type: |
other/unknown material |
| Language: |
unknown |
| DOI: |
10.21203/rs.3.rs-6905400/v1 |
| Availability: |
https://doi.org/10.21203/rs.3.rs-6905400/v1; https://www.researchsquare.com/article/rs-6905400/v1; https://www.researchsquare.com/article/rs-6905400/v1.html |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.F53C00B9 |
| Database: |
BASE |