| Title: |
Progression of bone and joint space deformity in patients with mild knee osteoarthritis:Data from the IMI-APPROACH cohort |
| Authors: |
Nguyen, H. Chien; Bax, Eva; Custers, Roel J.H.; van Egmond, Nienke; Kuiper, Ruurd J.A.; Arbabi, Vahid; Rayegan, Hassan; Gielis, Willem Paul; Sakkers, Ralph J.B.; Kloppenburg,Margreet; Blanco,Francisco J.; Haugen,Ida K.; Berenbaum,Francis; Jansen, Mylène P.; Mastbergen, Simon C.; Lindner,Claudia; Cootes,Tim F.; Weinans, Harrie; DHS 3D Lab; MS Orthopaedie Algemeen; Regenerative Medicine and Stem Cells; Datascience; ORT Research; Other research (not in main researchprogram); Orthopaedie Onderzoek; Lab Reumatologie/Klinische Immunologie; Infection & Immunity; MS Reumatologie/Immunologie/Infectie |
| Publication Year: |
2026 |
| Subject Terms: |
Biomedical Engineering; Orthopedics and Sports Medicine; Rehabilitation |
| Description: |
Objective: This study aimed to divide leg malalignment into different categories of valgus and varus of the femur, tibia, and intra-articular knee joint and investigates whether knee osteoarthritis (OA) patients are susceptible for changes of such leg deformities over time. Design: This study included 317 radiographs and CT-images on baseline and 24 months of 169 patients (median age 67, 78.2 % female) of the prospective European IMI-APPROACH cohort, enrolled for knee OA. Femoral, tibial, and intra-articular geometry was determined. Different categories were analysed based on varus or valgus in the femur, in the tibia, or within the intra-articular joint. Changes of these variables over time and their correlations were determined with mixed model analysis. Results: Femurs tended to become more varus-like over the two-year follow up (0.3°, 95 % CI 0.6°–0.1°, p = 0.02), bony valgus femurs became more varus shaped (1.1°, 95 % CI:1.7°–0.5°, p < 0.001). Patients with bone varus and a normal joint line convergence angle (JLCA) showed a significant increase in intra-articular joint varus, with a mean JLCA increase of 1.1°(95 % CI:0.4°–1.7°, p = 0.005). By two years, they reached the threshold for defining intra-articular joint varus deformity, with a JLCA of 2.0°. Conclusions: Substantial intra-articular joint and bone varus progression was observed within two years. This study shows that bone deformity is to some extent a dynamic process and there is a growing varus malalignment in the intra-articular knee joint and bones. Thereby this study emphasizes the importance of leg malalignment for progression of intra-articular knee joint changes in early OA. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
2665-9131 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/469596 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/469596 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.F56B0ADF |
| Database: |
BASE |