Multicentre Collaborative Prospective Cohort Study Investigating the Impact of Enhanced Recovery After Surgery on Kidney Transplant Outcomes: The CRAFT Study
| Title: | Multicentre Collaborative Prospective Cohort Study Investigating the Impact of Enhanced Recovery After Surgery on Kidney Transplant Outcomes: The CRAFT Study |
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| Authors: | Ruth Owen; Georgios Kourounis; Bishow Karki; Katie Connor; Charlotte Brown; Kayani Kayani; Mohamed Elzawahry; Ruth Blanco; Davide Schilirò; Paul Smith; Jenny Mehew; Miriam Manook; Carrie Scuffell; Aimen Amer; Samuel Tingle; Emily R. Thompson; CRAFT Study Collaborators; Lauren Hackney; Damian McGrogan; Clara Tohill; Shauna McBride; Isobel Austin; Dilan Dabare; Ugochukwu Okafor; Raja Rashid; Poppy Brown; Irena Radnaeva; Tariq Ghattas; Ahmed Radwan; Harry V. M. Spiers; Catriona Walker; Paula Appleton; Charlie Brown; Christopher Chalklin; Laszlo Szabo; Farhan Ahmad; Hamza Ahmad; Keno Mentor; Katie L. Connor; Rachel Thomas; Karen Clark; Neil McKane; Eksha Gupta; Robert Pearson; Emma Aitken; Aldo Alonso-Becerra; Jessica Weemes; Adam Barlow; Sadia Tasleem; Sunil Daga; Melissa Bautista; Amirh Azhar; George Nita; Petra Goldsmith; Caitlin Jordan; Benedict Phillips; Hannah Maple; Ahmed Hussein; Yasaman Nikooiyan; Fayyad Jaradat; Zoja Milovanovic; Rebecca Matthews; Mohammad Ayaz Hossain; Fiona McCaig; Baven Blanderan; James Sweatman; Christopher Seet; Muhammad Khurram; Ben Lindsey; Ismail Mohamed; Laura Clementoni; Hussein Khambalia; Malcom Greenwood-Morgan; Orus Erum; Emily Thompson; Tzer En Yap; Eleanor Kissane; Laura Kenny; Batool Almoosawi; Joe Dobbins; Sam Tingle; Jenny Nur; George Kourounis; Sarah Abdelbar; Hatem Sadik; Mohamed Aly M. El Shafei El Zawahry; Srikanth Reddy; Thomas Whitehead; Nasir Al-Karboolee; Muhammad Sheharyar Khan; Faraaz Khan; Balaji Mahendran; Charlotte Hitchins; Sundar Muneeswaran; Haitham Alzoubi; Catherine Boffa; Abris Szentpali; Bishow Bekhyat Karki; Yazine Marie; Ahmed Halwa |
| Source: | Transplant International, Vol 38 (2026) |
| Publisher Information: | Frontiers Media S.A. |
| Publication Year: | 2026 |
| Collection: | Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: | enhanced recovery after surgery (ERAS); ERAS in kidney transplantation; kidney; perioperative care; prehabilitation; Specialties of internal medicine; RC581-951 |
| Description: | Perioperative complications are common in kidney transplantation. Enhanced recovery after surgery (ERAS) is a well-established multimodal perioperative care pathway designed to improve patient outcomes, however, its efficacy in renal transplant remains poorly described. Participating centres included adult renal transplant recipients and 30-day follow-up data. The primary outcome was LOS. Multivariable hierarchical models compared cohorts. 213 patients were included in the study period. 18/23 UK kidney transplant centres were represented. Analysis of the perioperative care delivery demonstrated similar patterns irrespective of reported protocols, with a tendency towards ERAS-type care. Between cohorts, the incidence of complications were similar; formal ERAS 14.3%, ERAS informal 17.0%, no ERAS 12.6%; p = 0.64. Median LOS was also similar; formal ERAS 6.0 days (5.0–11.5), informal ERAS 7.0 days (5.0–10.5) vs. no ERAS 6.0 days (5.0–10.5); p = 0.75. Readmissions were comparable; p = 0.721. Multivariable models confirmed these findings and demonstrated frailer patients had longer LOS and more readmissions. Currently, most UK renal transplant centres deliver a form of peri-operative ERAS care, indicating broad adoption of ERAS principles. Consequently, a formal ERAS protocol is not associated with decreased complications, LOS or readmissions. Efforts to improve outcomes should focus on prehabilitation of at-risk groups on the waiting list. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | https://www.frontierspartnerships.org/articles/10.3389/ti.2025.15541/full; https://doaj.org/toc/1432-2277; https://doaj.org/article/ed5dc114481f4789b4d75b4ff61cef6f |
| DOI: | 10.3389/ti.2025.15541 |
| Availability: | https://doi.org/10.3389/ti.2025.15541; https://doaj.org/article/ed5dc114481f4789b4d75b4ff61cef6f |
| Accession Number: | edsbas.F5C09EC |
| Database: | BASE |