| Title: |
Metabolic syndrome associates with left atrial dysfunction |
| Authors: |
Nyman, K.; Granér, M.; Pentikäinen, M.O.; Lundbom, J.; Hakkarainen, A.; Sirén, R.; Nieminen, M.S.; Taskinen, M.-R.; Lundbom, N.; Lauerma, K. |
| Contributors: |
Department of Diagnostics and Therapeutics; University of Helsinki; Clinicum; HUS Medical Imaging Center; HUS Heart and Lung Center; Marja-Riitta Taskinen Research Group; Kardiologian yksikkö; CAMM - Research Program for Clinical and Molecular Metabolism; Research Programs Unit; Department of Medicine; Department of General Practice and Primary Health Care; HUS Internal Medicine and Rehabilitation |
| Publisher Information: |
Elsevier B.V. |
| Publication Year: |
2019 |
| Collection: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| Subject Terms: |
Cardiovascular magnetic resonance; proton magnetic resonance spectroscopy; metabolic syndrome; obesity; left atrial; ejection fraction; atrial remodeling; visceral adipose tissue; cardiac steatosis; General medicine; internal medicine and other clinical medicine; Surgery; anesthesiology; intensive care; radiology |
| Description: |
Background and aims: Obesity and metabolic syndrome (MetS) are risk factors of atrial fibrillation (AF), but limited data exist on their effect on left atrial (LA) function. The aim of the study was to evaluate the effects of cardiac, hepatic and intra-abdominal ectopic fat depots and cardiometabolic risk factors on LA function in non-diabetic male subjects. Methods and results: Myocardial and hepatic triglyceride contents were measured with 1.5T H-1-magnetic resonance spectroscopy and LA and left ventricular function, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), epicardial and pericardial fat by magnetic resonance imaging (MRI) in 33 men with MetS and 40 men without MetS. LA volumes were assessed using a novel three-chamber orientation based MRI approach. LA ejection fraction (EF) was lower in MetS patients than in the control group (44 +/- 7.7% in MetS vs. 49 +/- 8.6% in controls, p = 0.013) without LA enlargement, indicating LA dysfunction. LA EF correlated negatively with waist circumference, body mass index, SAT, VAT, fasting serum insulin, and homeostasis model assessment of insulin resistance index, and positively with fasting serum high-density lipoprotein cholesterol. VAT was the best predictor of reduced LA EF. Conclusions: MetS associates with subclinical LA dysfunction. Multiple components of MetS are related to LA dysfunction, notably visceral obesity and insulin resistance. Further studies are needed to elucidate the role of mechanical atrial remodeling in the development of AF. (C) 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. ; Peer reviewed |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
RIS: urn:CF3D7DBF7850CDC755ECA2FB1359ECB0; https://hdl.handle.net/10138/299272; 85047209578; 000435224800011 |
| Availability: |
https://hdl.handle.net/10138/299272 |
| Rights: |
cc_by_nc_nd ; info:eu-repo/semantics/openAccess ; openAccess |
| Accession Number: |
edsbas.F5F302D8 |
| Database: |
BASE |