| Title: |
Primary central nervous system lymphoma—current standards and recent developments |
| Authors: |
Van Der Meulen, Matthijs; Vermaat, Joost S P; Galldiks, Norbert; Issa, Samar; De Bresser, Jeroen; Doorduijn, Jeanette K; Bromberg, Jacoline E C |
| Source: |
Neuro-Oncology Practice ; ISSN 2054-2577 2054-2585 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2026 |
| Description: |
Primary central nervous system lymphoma (PCNSL) is a rare aggressive B-cell non-Hodgkin lymphoma confined to the central nervous system, without systemic involvement. The incidence has increased over the past 3 decades. The prognosis has improved in patients up to 70 years old, and this type of lymphoma can be potentially cured. The gold standard of diagnosing PCNSL is histological, usually on a brain biopsy specimen via a neurosurgical procedure. Recent developments in both imaging and laboratory analyses of the cerebrospinal fluid, can be helpful in narrowing the differential diagnosis, diagnosing PCNSL itself, and in follow-up after treatment. This narrative review gives an overview of the epidemiology, diagnosis, and treatment of PCNSL, with an emphasis on recent developments in diagnostic techniques and treatment. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/nop/npag016 |
| DOI: |
10.1093/nop/npag016/67077403/npag016.pdf |
| Availability: |
https://doi.org/10.1093/nop/npag016; https://academic.oup.com/nop/advance-article-pdf/doi/10.1093/nop/npag016/67077403/npag016.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.F602A3E5 |
| Database: |
BASE |