| Title: |
The Impact and Burden of Chronic Rhinosinusitis with Nasal Polyps on Patients and Their Family Caregivers: A Nationally Representative Survey |
| Authors: |
Malvezzi L.; Seccia V.; Moffa A.; Canevari F. R. M.; Baiardini I.; Barbaglia S.; Battistini M.; Cantoni E.; Cipriani F.; Pirronello M.; Sala G.; Stassaldi A.; De Corso E. |
| Contributors: |
Malvezzi, L.; Seccia, V.; Moffa, A.; Canevari, F. R. M.; Baiardini, I.; Barbaglia, S.; Battistini, M.; Cantoni, E.; Cipriani, F.; Pirronello, M.; Sala, G.; Stassaldi, A.; De Corso, E. |
| Publication Year: |
2025 |
| Collection: |
IRIS Università degli Studi di Perugia |
| Subject Terms: |
caregiver burden; chronic rhinosinusitis with nasal polyps; disease burden; emotional burden; everyday living; patient journey; productivity loss; snoring; symptoms |
| Description: |
Background: Chronic rhinosinusitis with nasal polyps (CRSwNPs) is a chronic inflammatory disease associated with frustrating symptoms, particularly nasal obstruction and loss of smell. We conducted a patient survey on the significant burden of the disease, with a specific focus on conditions that affect health, sleep quality, absenteeism, and presenteeism, including the caregivers’ perspectives. Methods: An online questionnaire was sent to 4230 randomly selected recipients, and 200 matched the inclusion criteria for self-reported CRSwNPs symptoms. A total of 100 participants not matching the inclusion criteria for CRSwNPs were recruited as a control group. The study also collected the perspectives of 50 caregivers. Results: Patients with CRSwNPs experienced very bothersome symptoms, such as nasal congestion, headache, and rhinorrhoea, with a profound impact on their health-related quality of life (HRQoL). The patients and their caregivers showed significantly lower quality of sleep, experiencing a poor night’s sleep on average 72.1 and 51.7 days per year, respectively. Smell and taste impairments significantly impacted patients’ social and working lives, with 39.5% feeling in danger because of hyposmia and 34.5% because of limited taste. Out-of-pocket costs were up to EUR 40/month for 68.5% of patients. CRSwNPs alone was responsible for an average of 24.7 days of absenteeism and 25.1 days of presenteeism. Conclusions: Our results highlight how CRSwNPs has a negative impact on patients’ and caregivers’ HRQoL. Most bothersome and health-conditioning symptoms involve nose symptoms and poor sleep quality, resulting in patient absenteeism and presenteeism with a strong burden on cognitive and emotional functioning for both patients and their caregivers. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
volume:13; issue:4; journal:HEALTHCARE; https://hdl.handle.net/11391/1617364 |
| DOI: |
10.3390/healthcare13040430 |
| Availability: |
https://hdl.handle.net/11391/1617364; https://doi.org/10.3390/healthcare13040430 |
| Accession Number: |
edsbas.F6256D43 |
| Database: |
BASE |