| Title: |
Tailored analytical strategies for AAV aggregation: purpose‑driven method selection for enhanced product development |
| Authors: |
Zhao, Yan; Wang, Lin; Reeves, John S; Shi, Wen; Liu, Nina; Yu, Yan; Luo, Lin; Abdubek, Polat; O’Grady, Glynn; Shevade, Aishwarya; Cao, Yuan; Wang, Serena; Rosconi, Michael; Graham, Kenneth; Liu, Dingjiang; Shameem, Mohammed; Tustian, Andrew D |
| Source: |
Cell and Gene Therapy Insights ; volume 12, issue 2, page 215–229 ; ISSN 2059-7800 |
| Publisher Information: |
BioInsights Publishing, Ltd. |
| Publication Year: |
2026 |
| Description: |
No single analytical method captures all AAV aggregation species across all conditions. A purpose-driven framework for selecting SEC-UV, SEC-FLD, DLS, and A4F – what each method detects, where each fails, and how to combine them for release testing, stability studies, and forced degradation. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.18609/cgti.2026.029 |
| Availability: |
https://doi.org/10.18609/cgti.2026.029 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.F625F153 |
| Database: |
BASE |