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Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

Title:	Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus
Authors:	Mahajan A; Sim X; Ng HJ; Manning A; Rivas MA; Highland HM; Locke AE; Grarup N; Im HK; Cingolani P; Flannick J; Fontanillas P; Fuchsberger C; Gaulton KJ; Teslovich TM; Rayner NW; Robertson NR; Beer NL; Rundle JK; Bork-Jensen J; Ladenvall C; Blancher C; Buck D; Buck G; Burtt NP; Gabriel S; Gjesing AP; Groves CJ; Hollensted M; Huyghe JR; Jackson AU; Jun G; Justesen JM; Mangino M; Murphy J; Neville M; Onofrio R; Small KS; Stringham HM; Syvanen A-C; Trakalo J; Abecasis G; Bell GI; Blangero J; Cox NJ; Duggirala R; Hanis CL; Seielstad M; Wilson JG; Christensen C; Brandslund I; Rauramaa R; Surdulescu GL; Doney ASF; Lannfelt L; Linneberg A; Isomaa B; Tuomi T; Jorgensen ME; Jorgensen T; Kuusisto J; Uusitupa M; Salomaa V; Spector TD; Morris AD; Palmer CNA; Collins FS; Mohlke KL; Bergman RN; Ingelsson E; Lind L; Tuomilehto J; Hansen T; Watanabe RM; Prokopenko I; Dupuis J; Karpe F; Groop L; Laakso M; Pedersen O; Florez JC; Morris AP; Altshuler D; Meigs JB; Boehnke M; McCarthy MI; Lindgren CM; Gloyn AL; Abboud HE; Afzal U; Aguilar D; Arya R; Atzmon G; Aung T; Banks E; Barroso I; Barzilai N; Below JE; Bharadwaj D; Blackwell TW; Bonnycastle LL; Bowden D; Carey J; Carneiro MO; Chambers JC; Chan E; Chan J; Chandak GR; Chen P; Chen Y; Chen H; Cheng C-Y; Chia KS; Cho YS; Correa A; Curran JE; Daly MJ; Day-Williams AG; DeFronzo RA; DePristo M; Donnelly PJ; Ebrahim SB; Elliott P; Esko T; Fadista J; Farjoun Y; Farmer AJ; Farook VS; Fennell T; Ferreira T; Fingerlin T; Forsen T; Fowler SP; Franks PW; Frayling TM; Freedman BI; Froguel P; Gamazon ER; Gieger C; Glaser B; Go MJ; Goldstein JI; Grallert H; Grant G; Green T; Griswold M; Hale DE; Han B-G; Hartl C; Hattersley AT; Hicks PJ; Hodgkiss D; Horikoshi M; Hrabe de Angelis M; Hu C; Hu FB; Huh I; Kamran Ikram M; Illig T; Jablonski KA; Jenkinson CP; Jia W; Kang HM; Khor C-C; Kim Y; Kim YJ; Kim B-J; Kinnunen L; Kooner JS; Kravic J; Kriebel J; Kumar A; Kumar S; Kuulasmaa T; Kwon M-S; Langenberg C; Lauritzen T; Lee S; Lee J; Lee J-Y; Lehman DM; Lehne B; Levy JC; Li J; Liang L; Lim WY; Lin K-H; Liu J; Loh M; Ma RCW; Ma C; Magi R; Maguire J; Maxwell TJ; McVean G; Meisinger C; Meitinger T; Melander O; Metspalu A; Mihailov E; Milani L; Moutsianas L; Muller-Nurasyid M; K Musani S; Nagai Y; Narisu N; Neale BM; Ng MCY; Nilsson P; O'Rahilly SP; Orho-Melander M; Owen KR; Palmer ND; Park T; Pasko D; Pearson RD; Perry JRB; Peters A; Pollin TI; Poplin R; Prabhakaran D; Puppala S; Purcell S; Qi L; Qi Q; Roden M; Rolandsson O; Rosengren AH; Sandhu M; Schwarzmayr T; Scott LJ; Scott RA; Scott J; Scott WR; Sehmi J; Shakir K; Sladek R; Smith JD; Stancakova A; Strauch K; Strom TM; Swift A; Tai ES; Tajes JF; Tan S-T; Tandon N; Taylor HA; Teo YY; Thameem F; Thorand B; van de Bunt M; Varga TV; Walker M; Wareham NJ; Welch RP; Wieland T; Wilson G; Wong TY; Wood AR; Yoon J; Zeggini E; Zhang W
Source:	PLoS Genetics, 27 January 2015
Publisher Information:	Public Library of Science
Publication Year:	2015
Collection:	Newcastle University Library ePrints Service
Description:	© 2015, Public Library of Science, All Rights Reserved.Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contribute substantially to unexplained genetic variance. To test this, we analyzed exome-array data from up to 33,231 non-diabetic individuals of European ancestry. We found exome-wide significant (P
Document Type:	article in journal/newspaper
Language:	unknown
Relation:	https://eprints.ncl.ac.uk/234644
Availability:	https://eprints.ncl.ac.uk/234644
Accession Number:	edsbas.F6347E4D
Database:	BASE