| Title: |
The impact of long-term moderate and heavy alcohol consumption on incident atherosclerosis among persons living with HIV |
| Authors: |
Kelso-Chichetto, NE; Plankey, M; Sheps, DS; Abraham, AG; Chen, X; Shoptaw, S; Kaplan, RC; Post, WS; Cook, RL |
| Source: |
Drug and Alcohol Dependence, vol 181 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2017 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 4206 Public Health (for-2020); 42 Health Sciences (for-2020); Atherosclerosis (rcdc); Heart Disease (rcdc); Alcoholism; Alcohol Use and Health (rcdc); Cardiovascular (rcdc); Infectious Diseases (rcdc); Sexually Transmitted Infections (rcdc); Aging (rcdc); Substance Misuse (rcdc); Prevention (rcdc); Clinical Research (rcdc); HIV/AIDS (rcdc); Women's Health (rcdc); Cardiovascular (hrcs-hc); 3 Good Health and Well Being (sdg); Adult (mesh); Alcohol Drinking (mesh); Atherosclerosis (mesh); Carotid Intima-Media Thickness (mesh); Cohort Studies (mesh); Female (mesh); HIV Infections (mesh); Humans (mesh); Incidence (mesh); Male (mesh); Middle Aged (mesh); Protective Factors (mesh) |
| Subject Geographic: |
235 - 241 |
| Description: |
BACKGROUND: Level of alcohol consumption is associated with differential risk of atherosclerosis, but little research has investigated this association among HIV+ persons. We evaluated the association between long-term alcohol use and incident atherosclerosis among HIV+ persons. METHODS: We utilized data from HIV+ participants of the Women's Interagency HIV Study (n=483) and the Multicenter AIDS Cohort Study (n=305) without history of cardiovascular disease. Atherosclerosis was assessed two times by B-mode carotid artery ultrasound imaging from 2004 to 2013. Presence of plaque was defined as focal carotid intima-media thickness over 1.5mm. Those with no plaque at baseline and plaque at follow-up were considered incident cases of atherosclerosis. Group-based trajectory models were used to categorize participants into 10-year drinking patterns representing heavy, moderate, or abstinent-low. Multivariable logistic regressions were conducted to assess the association of long-term moderate and heavy use on atherosclerosis, compared to abstinent-low. RESULTS: Heavy alcohol consumption was not statistically significantly associated with risk for incident atherosclerosis in women (AOR 1.10, CI 0.40-3.02) or men (AOR 1.31, CI 0.43-4.00), compared to abstinence-low. Moderate consumption was associated with 54% lower odds for incident disease in men (AOR 0.46, CI 0.21-1.00), but not in women (AOR 1.08, CI 0.58-2.00). In cohort-combined analyses, alcohol consumption was not statistically significantly association with incident atherosclerosis (moderate AOR 0.78, CI 0.48-1.27; heavy AOR 1.33, CI 0.66-2.69). CONCLUSION: Moderate alcohol consumption was associated with a significant protective effect on incident atherosclerosis in men only. No other levels of alcohol consumption significantly predicted atherosclerosis in men and women compared to abstinent-low. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt5xf7z6v5; https://escholarship.org/uc/item/5xf7z6v5; https://escholarship.org/content/qt5xf7z6v5/qt5xf7z6v5.pdf |
| DOI: |
10.1016/j.drugalcdep.2017.09.034 |
| Availability: |
https://escholarship.org/uc/item/5xf7z6v5; https://escholarship.org/content/qt5xf7z6v5/qt5xf7z6v5.pdf; https://doi.org/10.1016/j.drugalcdep.2017.09.034 |
| Rights: |
public |
| Accession Number: |
edsbas.F642EEEE |
| Database: |
BASE |