| Title: |
Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection |
| Authors: |
Li, Amanda; Coffey, Lark L; Mohr, Emma L; Raper, Jessica; Chahroudi, Ann; Ausderau, Karla K; Aliota, Matthew T; Friedrich, Thomas C; Mitzey, Ann M; Koenig, Michelle R; Golos, Thaddeus G; Jaeger, Hannah K; Roberts, Victoria HJ; Lo, Jamie O; Smith, Jessica L; Hirsch, Alec J; Streblow, Daniel N; Newman, Christina M; O’Connor, David H; Lackritz, Eve M; Van Rompay, Koen KA; Waldorf, Kristina M Adams; Workgroup, Zika Expert; Barrett, Alan DT; Beasley, David WC; Bennie, JosephY B; Bourne, Nigel; Brault, Aaron C; Cehovin, Ana; Coelho, Christiane; Diamond, Michael S; Emperador, Devy; Faria, Nuno R; Fay, Petra C; Golding, Josephine P; Harris, Eva; Hasanin, Nagwa; Jaenisch, Thomas; Ko, Albert I; Leighton, Tabitha; Leo, Yee-Sin; Mehr, Angela J; Memish, Ziad A; Méndez-Rico, Jairo A; Moore, Kristine A; Mura, Manuela; Ng, Lee-Ching; Osterholm, Michael T; Ostrowsky, Julia T; Peeling, Rosanna W; Rabe, Ingrid B; Salje, Henrik; Staples, J Erin; Thomas, Stephen J; Ulrich, Angela K; Vanhomwegen, Jessica; Wongsawat, Jurai |
| Source: |
The Lancet Microbe, vol 6, iss 6 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2025 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
Medical Microbiology; Biomedical and Clinical Sciences; Biodefense; Vector-Borne Diseases; Pediatric; Rare Diseases; Emerging Infectious Diseases; Physical Injury - Accidents and Adverse Effects; Infectious Diseases; 2.2 Factors relating to the physical environment; Infection; Good Health and Well Being; Zika Virus Infection; Animals; Disease Models; Animal; Zika Virus; Primates; Humans; Pregnancy; Microcephaly; Female; Zika Expert Workgroup; Microbiology; Immunology |
| Description: |
Zika virus, a mosquito-transmitted orthoflavivirus, has become a pathogen of global health concern ever since the virus caused an epidemic in Brazil in 2015 associated with approximately 700 000 laboratory-confirmed cases of congenital microcephaly. The subsequent spread of the epidemic in 2016 resulted in a wide spectrum of congenital neurological, ophthalmological, and developmental abnormalities across the Americas, Africa, and Asia. In this context, non-human primate models have become essential tools for Zika virus research to understand the pathogenesis of congenital brain injury and perinatal complications and for developing and testing medical countermeasures such as vaccines, diagnostics, and therapeutics. Fetal brain injury has been observed across various non-human primate species and is influenced by factors such as the Zika virus strain, gestational age at inoculation, and inoculation dose and route. Miscarriages are also seen as common outcomes of first trimester Zika virus infections. This Series paper reviews the diverse non-human primate models currently used for Zika virus research to mitigate the public health effects of future Zika virus epidemics. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt2cg0w5vz; https://escholarship.org/uc/item/2cg0w5vz; https://escholarship.org/content/qt2cg0w5vz/qt2cg0w5vz.pdf |
| DOI: |
10.1016/j.lanmic.2024.101030 |
| Availability: |
https://escholarship.org/uc/item/2cg0w5vz; https://escholarship.org/content/qt2cg0w5vz/qt2cg0w5vz.pdf; https://doi.org/10.1016/j.lanmic.2024.101030 |
| Rights: |
CC-BY-NC-ND |
| Accession Number: |
edsbas.F66D1AF3 |
| Database: |
BASE |