| Title: |
Associations of prenatal ambient air pollution exposures with asthma in middle childhood |
| Authors: |
Hazlehurst, Marnie F; Carroll, Kecia N; Moore, Paul E; Szpiro, Adam A; Adgent, Margaret A; Dearborn, Logan C; Sherris, Allison R; Loftus, Christine T; Ni, Yu; Zhao, Qi; Barrett, Emily S; Nguyen, Ruby HN; Swan, Shanna H; Wright, Rosalind J; Bush, Nicole R; Sathyanarayana, Sheela; LeWinn, Kaja Z; Karr, Catherine J |
| Source: |
International Journal of Hygiene and Environmental Health, vol 258 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2024 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
4202 Epidemiology (for-2020); 42 Health Sciences (for-2020); Conditions Affecting the Embryonic and Fetal Periods (rcdc); Climate-Related Exposures and Conditions (rcdc); Clinical Research (rcdc); Pediatric Research Initiative (rcdc); Lung (rcdc); Health Disparities (rcdc); Perinatal Period - Conditions Originating in Perinatal Period (rcdc); Asthma (rcdc); Women's Health (rcdc); Social Determinants of Health (rcdc); Health Effects of Indoor Air Pollution (rcdc); Pregnancy (rcdc); Health Disparities and Racial or Ethnic Minority Health Research (rcdc); 2.2 Factors relating to the physical environment (hrcs-rac); Respiratory (hrcs-hc); Reproductive health and childbirth (hrcs-hc); 3 Good Health and Well Being (sdg); Child (mesh); Pregnancy (mesh); Female (mesh); Humans (mesh); Respiratory Sounds (mesh); Air Pollution (mesh); Air Pollutants (mesh); Asthma (mesh); Particulate Matter (mesh); Nitrogen Dioxide (mesh); Environmental Exposure (mesh) |
| Description: |
We examined associations between prenatal fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3) exposures and child respiratory outcomes through age 8-9 years in 1279 ECHO-PATHWAYS Consortium mother-child dyads. We averaged spatiotemporally modeled air pollutant exposures during four fetal lung development phases: pseudoglandular (5-16 weeks), canalicular (16-24 weeks), saccular (24-36 weeks), and alveolar (36+ weeks). We estimated adjusted relative risks (RR) for current asthma at age 8-9 and asthma with recent exacerbation or atopic disease, and odds ratios (OR) for wheezing trajectories using modified Poisson and multinomial logistic regression, respectively. Effect modification by child sex, maternal asthma, and prenatal environmental tobacco smoke was explored. Across all outcomes, 95% confidence intervals (CI) included the null for all estimates of associations between prenatal air pollution exposures and respiratory outcomes. Pseudoglandular PM2.5 exposure modestly increased risk of current asthma (RRadj=1.15, 95% CI: 0.88-1.51); canalicular PM2.5 exposure modestly increased risk of asthma with recent exacerbation (RRadj=1.26, 95% CI: 0.86-1.86) and persistent wheezing (ORadj=1.28, 95% CI: 0.86-1.89). Similar findings were observed for O3, but not NO2, and associations were strengthened among mothers without asthma. While not statistically distinguishable from the null, trends in effect estimates suggest some adverse associations of early pregnancy air pollution exposures with child respiratory conditions, warranting confirmation in larger samples. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt0q91j369; https://escholarship.org/uc/item/0q91j369; https://escholarship.org/content/qt0q91j369/qt0q91j369.pdf |
| DOI: |
10.1016/j.ijheh.2024.114333 |
| Availability: |
https://escholarship.org/uc/item/0q91j369; https://escholarship.org/content/qt0q91j369/qt0q91j369.pdf; https://doi.org/10.1016/j.ijheh.2024.114333 |
| Rights: |
CC-BY-NC |
| Accession Number: |
edsbas.F6BF7C81 |
| Database: |
BASE |