| Title: |
From genetic mosaicism to tumorigenesis through indirect genetic effects |
| Authors: |
Capp, Jean‐pascal; Catania, Francesco; Thomas, Frédéric |
| Contributors: |
Toulouse Biotechnology Institute (TBI); Institut National des Sciences Appliquées - Toulouse (INSA Toulouse); Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Fukushima University Fukushima, Japan; Centre de Recherches Ecologiques et Evolutives sur le Cancer (MIVEGEC-CREEC); Processus Écologiques et Évolutifs au sein des Communautés (PEEC); Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC); Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM)-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC); Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM); Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM); ANR-23-CE13-0007,EVOSEXCAN,Reproduction sexuée, traits d'histoire de vie, sex ratio et processus oncogéniques(2023) |
| Source: |
ISSN: 0265-9247. |
| Publisher Information: |
CCSD; Wiley-VCH Verlag |
| Publication Year: |
2024 |
| Collection: |
Université de Montpellier: HAL |
| Subject Terms: |
Cell-cell communications; Cellular stochasticity; Genetic mosaicism; Indirect genetic effects; Phenotypic instability; Tissue disruption; Tissue homeostasis; [SDV.CAN]Life Sciences [q-bio]/Cancer; [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics |
| Description: |
International audience ; Genetic mosaicism has long been linked to aging, and several hypotheses have been proposed to explain the potential connections between mosaicism and susceptibility to cancer. It has been proposed that mosaicism may disrupt tissue homeostasis by affecting intercellular communications and releasing microenvironmental constraints within tissues. The underlying mechanisms driving these tissue‐level influences remain unidentified, however. Here, we present an evolutionary perspective on the interplay between mosaicism and cancer, suggesting that the tissue‐level impacts of genetic mosaicism can be attributed to Indirect Genetic Effects (IGEs). IGEs can increase the level of cellular stochasticity and phenotypic instability among adjacent cells, thereby elevating the risk of cancer development within the tissue. Moreover, as cells experience phenotypic changes in response to challenging microenvironmental conditions, these changes can initiate a cascade of nongenetic alterations, referred to as Indirect non‐Genetic Effects (InGEs), which in turn catalyze IGEs among surrounding cells. We argue that incorporating both InGEs and IGEs into our understanding of the process of oncogenic transformation could trigger a major paradigm shift in cancer research with far‐reaching implications for practical applications. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38736323; PUBMED: 38736323; WOS: 001219025700001 |
| DOI: |
10.1002/bies.202300238 |
| Availability: |
https://hal.science/hal-04618450; https://hal.science/hal-04618450v1/document; https://hal.science/hal-04618450v1/file/BioEssays%20-%202024%20-%20Capp%20-%20From%20genetic%20mosaicism%20to%20tumorigenesis%20through%20indirect%20genetic%20effects.pdf; https://doi.org/10.1002/bies.202300238 |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.F6D3DB17 |
| Database: |
BASE |