| Title: |
Circulating memory is sufficient for protective immunity to infection with Chlamydia muridarum |
| Authors: |
Labuda, Jasmine C; McSorley, Stephen J |
| Source: |
The Journal of Immunology ; volume 204, issue 1_Supplement, page 82.19-82.19 ; ISSN 0022-1767 1550-6606 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2020 |
| Description: |
Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection worldwide and yet no vaccine currently exists to protect the public from this reproductive tract pathogen. Recent reports suggest that CD4 tissue resident memory cells (TRM) are essential for vaccine-induced protection against Chlamydia trachomatis in a mouse infection model. Additionally, CD4 TRM in the female reproductive tract (FRT) have been shown to co-localize with APCs in memory lymphocyte clusters (MLCs) to enhance secondary adaptive immunity to reproductive tract infections. Here, we examine a requirement for CD4 TRM and MLCs in protective immunity against infection with Chlamydia muridarum (Cm). Using parabiosis of naïve and Chlamydia-immune mice, we demonstrate that although CD4 TRM form in the FRT after primary Cm infection, they are not required for protection. Furthermore, histological analysis of FRT tissue from parabionts revealed that circulating memory is sufficient for protection against intravaginal challenge with Cm in the absence of CD4 TRM or MLCs in the reproductive tract. Moreover, this protective circulating memory can be induced through intravaginal or intranasal challenge with Chlamydia, indicating that a strong mucosal immunization can generate circulating protection in a vaccine setting. Ongoing work using adoptive transfers and antibody depletions of CD4 T cells and B cells will reveal which memory lymphocytes are responsible for the observed circulating protection. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.4049/jimmunol.204.supp.82.19 |
| Availability: |
https://doi.org/10.4049/jimmunol.204.supp.82.19; https://academic.oup.com/jimmunol/article/204/1_Supplement/82.19/7948420 |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.F6DC4778 |
| Database: |
BASE |