| Title: |
Moderate Low UVB Irradiation Modulates Tumor‐associated Macrophages and Dendritic Cells and Promotes Antitumor Immunity in Tumor‐bearing Mice † |
| Authors: |
Park, Gayoung; Cui, Yan‐Hong; Yang, Seungwon; Sun, Ming; Wilkinson, Emma; Li, Haixia; Zhang, Yuhan Blair; Chen, Jing; Bissonnette, Marc; Lin, Wenbin; He, Yu‐Ying |
| Contributors: |
National Cancer Institute; National Institute of Environmental Health Sciences |
| Source: |
Photochemistry and Photobiology ; volume 99, issue 2, page 850-856 ; ISSN 0031-8655 1751-1097 |
| Publisher Information: |
Wiley |
| Publication Year: |
2022 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Excessive, high doses of ultraviolet B (UVB) UVB irradiation are known to cause skin cancer, aging and immunosuppression. On the contrary, moderate low doses of UVB irradiation are shown to be essential and beneficial to human health, including a tumor‐suppressive effect. However, the mechanism by which low levels of UVB suppress tumorigenesis remains unclear. Here, using tumor‐bearing mouse models, we show that moderate low repetitive UVB irradiation increases the percentage of activated CD4 + and CD8 + T cells, and CD103 + conventional type 1 dendritic cells (cDC1s), while it decreases the number of immunosuppressive, M2‐like macrophages in the tumors. Finally, in mice, deletion of Batf3, a transcription factor critical for the development of conventional dendritic cells, including the CD103 + cDC1s, showed increased tumor growth in both sham‐ and UVB‐irradiated mice. Our findings demonstrate that moderate low UVB irradiation inhibits M2‐like tumor‐associated macrophages, increases CD103 + cDC1s and promotes antitumor immunity in mice with an established tumor. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/php.13684 |
| Availability: |
https://doi.org/10.1111/php.13684; https://onlinelibrary.wiley.com/doi/pdf/10.1111/php.13684; https://onlinelibrary.wiley.com/doi/full-xml/10.1111/php.13684 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.F6E785CD |
| Database: |
BASE |