Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study)
| Title: | Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study) |
|---|---|
| Authors: | Kretschmer, J.R.; Tkachenko, D.; Kümpfel, T.; Havla, J.; Engels, D.; Paul, F.; Schindler, P.; Bellmann-Strobl, J.; Berthele, A.; Giglhuber, K.; Zappe, C.; Klotz, L.; Revie, L.; Dawin, E.; Senel, M.; Tumani, H.; Bergh, F.T.; Warnke, C.; Kraemer, M.; Walter, A.; Bayas, A.; Zettl, U.K.; Lauenstein, A.S.; Yalachkov, Y.; Etgen, T.; Kaste, M.; Luessi, F.; Gingele, S.; Passoke, S.; Weber, M.S.; Sieb, J.P.; Haarmann, A.; Oschmann, P.; Rothhammer, V.; Geis, C.; Kowarik, M.C.; Kern, P.; Grothe, M.; Stephanik, H.; Angstwurm, K.; Hoffmann, F.; Wallwitz, U.; Wildemann, B.; Jarius, S.; Stellmann, J.P.; Pakeerathan, T.; Schwake, C.; Ayzenberg, I.; Kleiter, I.; Fischer, K.; Aktas, O.; Ringelstein, M.; Häußler, V.; Trebst, C.; Hümmert, M.W. |
| Publisher Information: | Frontiers Media SA |
| Publication Year: | 2025 |
| Collection: | Max-Delbrueck-Center for Molecular Medicine, Berlin: MDC Repository |
| Subject Terms: | Function and Dysfunction of the Nervous System; Topic 3: Integrative Biomedicine |
| Description: | OBJECTIVE: This study analyzed clinical characteristics, attack recovery and long-term disability accumulation in late-onset (LO ≥ 50 years at onset) versus early-onset (EO < 50 years) NMOSD. METHODS: This multicenter cohort study included demographic and clinical data from 446 NMOSD patients collected from 35 German Neuromyelitis Optica Study Group (NEMOS) centers. Time to disability milestones was estimated through Kaplan-Meier analysis and Cox proportional hazard regression models adjusted for sex, year of onset, immunotherapy exposure and antibody status. Generalized estimating equations (GEE) were used to compare attack outcomes. RESULTS: Of the 446 NMOSD patients analyzed (83.4% female, 85.4% AQP4-IgG-positive, median age at disease onset = 43 years), 153 had a late-onset (34.3%). AQP4-IgG+ prevalence was higher in LO- than in EO-NMOSD (94.1% vs. 80.9%, p |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| Relation: | https://edoc.mdc-berlin.de/id/eprint/25322/1/25322oa.pdf; https://edoc.mdc-berlin.de/id/eprint/25322/2/25322suppl.pdf; Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study). Kretschmer, J.R., Tkachenko, D., Kümpfel, T., Havla, J., Engels, D., Paul, F., Schindler, P., Bellmann-Strobl, J., Berthele, A., Giglhuber, K., Zappe, C., Klotz, L., Revie, L., Dawin, E., Senel, M., Tumani, H., Bergh, F.T., Warnke, C., Kraemer, M., Walter, A., Bayas, A., Zettl, U.K., Lauenstein, A.S., Yalachkov, Y., Etgen, T., Kaste, M., Luessi, F., Gingele, S., Passoke, S., Weber, M.S., Sieb, J.P., Haarmann, A., Oschmann, P., Rothhammer, V., Geis, C., Kowarik, M.C., Kern, P., Grothe, M., Stephanik, H., Angstwurm, K., Hoffmann, F., Wallwitz, U., Wildemann, B., Jarius, S., Stellmann, J.P., Pakeerathan, T., Schwake, C., Ayzenberg, I., Kleiter, I., Fischer, K., Aktas, O., Ringelstein, M., Häußler, V., Trebst, C. and Hümmert, M.W. Frontiers in Immunology 16 : 1575613. 11 April 2025; PMID:40292288; https://doi.org/10.3389/fimmu.2025.1575613 |
| DOI: | 10.3389/fimmu.2025.1575613 |
| Availability: | https://edoc.mdc-berlin.de/id/eprint/25322/; https://edoc.mdc-berlin.de/25322/; https://doi.org/10.3389/fimmu.2025.1575613 |
| Rights: | cc_by_4 |
| Accession Number: | edsbas.F741AEC3 |
| Database: | BASE |