| Title: |
Identifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations |
| Authors: |
van Os, Jim; Rutten, Bart P.; Myin-Germeys, Inez; Delespaul, Philippe; Viechtbauer, Wolfgang; van Zelst, Catherine; Bruggeman, Richard; Reininghaus, Ulrich; Morgan, Craig; Murray, Robin M.; Di Forti, Marta; McGuire, Philip; Valmaggia, Lucia R.; Kempton, Matthew J.; Gayer-Anderson, Charlotte; Hubbard, Kathryn; Beards, Stephanie; Stilo, Simona A.; Onyejiaka, Adanna; Bourque, Francois; Modinos, Gemma; Tognin, Stefania; Calem, Maria; O'Donovan, Michael C.; Owen, Michael J.; Holmans, Peter; Williams, Nigel; Craddock, Nicholas; Richards, Alexander; Humphreys, Isla; Meyer-Lindenberg, Andreas; Leweke, F. Markus; Tost, Heike; Akdeniz, Ceren; Rohleder, Cathrin; Bumb, J. Malte; Schwarz, Emanuel; Alptekin, Koksal; Ucok, Alp; Saka, Meram Can; Atbasoglu, E. Cem; Guloksuz, Sinan; Gumus-Akay, Guvem; Cihan, Burin; Karadag, Hasan; Soygur, Haldan; Cankurtaran, Eylem Sahin; Ulusoy, Semra; Akdede, Berna; Binbay, Tolga; Ayer, Ahmet; Noyan, Handan; Karadayi, Gulsah; Akturan, Elin; Ulas, Halis; Arango, Celso; Parellada, Mara; Bernardo, Miguel; Sanjuan, Julio; Bobes, Julio; Arrojo, Manuel; Luis Santos, Jose; Cuadrado, Pedro; Rodriguez Solano, Jose Juan; Carracedo, Angel; Garcia Bernardo, Enrique; Roldan, Laura; Lopez, Gonzalo; Cabrera, Bibiana; Cruz, Sabrina; Diaz Mesa, Eva Ma; Pouso, Maria; Jimenez, Estela; Sanchez, Teresa; Rapado, Marta; Gonzalez, Emiliano; Martinez, Covadonga; Sanchez, Emilio; Soledad Olmeda, Ma; Haan, Lieuwe de; Velthorst, Eva; van der Gaag, Mark; Selten, Jean-Paul; van Dam, Daniella; van der Ven, Elsje; van der Meer, Floor; Messchaert, Elles; Kraan, Tamar; Burger, Nadine; Leboyer, Marion; Szoke, Andrei; Schurhoff, Franck; Llorca, Pierre-Michel; Jamain, Stephane; Tortelli, Andrea; Frijda, Flora; Vilain, Jeanne; Galliot, Anne-Marie; Baudin, Gregoire; Ferchiou, Aziz; Richard, Jean-Romain; Bulzacka, Ewa; Charpeaud, Thomas; Tronche, Anne-Marie; De Hert, Marc; van Winkel, Ruud; Decoster, Jeroen; Derom, Catherine; Thiery, Evert; Stefanis, Nikos C.; Sachs, Gabriele; Aschauer, Harald; Lasser, Iris; Winklbaur, Bernadette; Schlogelhofer, Monika; Riecher-Rossler, Anita; Borgwardt, Stefan; Walter, Anna; Harrisberger, Fabienne; Smieskova, Renata; Rapp, Charlotte; Ittig, Sarah; Soguel-Dit-Piquard, Fabienne; Studerus, Erich; Klosterkotter, Joachim; Ruhrmann, Stephan; Paruch, Julia; Julkowski, Dominika; Hilboll, Desiree; Sham, Pak C.; Cherny, Stacey S.; Chen, Eric Y. H.; Campbell, Desmond D.; Li, Miaoxin; Maria Romeo-Casabona, Carlos; Emaldi Cirion, Aitziber; Urruela Mora, Asier; Jones, Peter; Kirkbride, James; Cannon, Mary; Rujescu, Dan; Tarricone, Ilaria; Berardi, Domenico; Bonora, Elena; Seri, Marco; Marcacci, Thomas; Chiri, Luigi; Chierzi, Federico; Storbini, Viviana; Braca, Mauro; Minenna, Maria Gabriella; Donegani, Ivonne; Fioritti, Angelo; La Barbera, Daniele; La Cascia, Caterina Erika; Mule, Alice; Sideli, Lucia; Sartorio, Rachele; Ferraro, Laura; Tripoli, Giada; Seminerio, Fabio; Marinaro, Anna Maria; McGorry, Patrick; Nelson, Barnaby; Amminger, G. Paul; Pantelis, Christos; Menezes, Paulo R.; Del-Ben, Cristina M.; Tenan, Silvia H. Gallo; Shuhama, Rosana; Ruggeri, Mirella; Tosato, Sarah; Lasalvia, Antonio; Bonetto, Chiara; Ira, Elisa; Nordentoft, Merete; Krebs, Marie-Odile; Barrantes-Vidal, Neus; Cristobal, Paula; Kwapil, Thomas R.; Brietzke, Elisa UNIFESP; Bressan, Rodrigo A. UNIFESP; Gadelha, Ary UNIFESP; Maric, Nadja P.; Andric, Sanja; Mihaljevic, Marina; Mirjanic, Tijana; European Network Natl |
| Contributors: |
Maastricht Univ; Kings Coll London; Mondriaan Mental Hlth Trust; Univ Groningen; Cardiff Univ; Cent Inst Mental Hlth; Dokuz Eylul Univ; Istanbul Univ; Ankara Univ; Yale Univ; Middle E Tech Univ; Diskapi YB Res & Training Hosp; Turkish Federat Schizophrenia Assoc; Ataturk Training & Res Hosp; Manisa Mental Hlth Hosp; Univ Complutense; Univ Barcelona; Univ Valencia; Univ Oviedo; Univ Santiago de Compostela; Hosp Virgen de la Luz; Hosp Univ Infanta Leonor Hosp Virgen Torre; Hosp Clin Univ; Hosp Psiquiatr Conxo; Univ Amsterdam; Vrije Univ Amsterdam; EMGO Inst Hlth & Care Res; Parnassia Psychiat Inst; Rivierduinen Psychiat Inst; Grp Hosp Mondor; Hop Henri Mondor; Univ Paris Est; Fdn Fondamental; CMP B CHU; Univ Auvergne; EPS Maison Blanche; UPC KU Leuven; UPC; Katholieke Univ Leuven; Assoc Sci Res Multiple Births; Univ Ghent; Univ Athens; Med Univ Vienna; Psychiat Univ Clin Basel; Univ Cologne; Univ Hong Kong; Univ Basque Country; Univ Zaragoza; Univ Cambridge; UCL; Royal Coll Surgeons Ireland; Univ Munich; Univ Bologna; Local Hlth Trust; Univ Palermo; P Giaccone Gen Hosp; Univ Melbourne; Universidade de São Paulo (USP); Univ Verona; Copenhagen Univ Hosp; Univ Paris 05; Univ Autonoma Barcelona; St Pere Claver Fundacio Sanitaria; Univ N Carolina; CIBERSAM; Universidade Federal de São Paulo (UNIFESP); Univ Belgrade |
| Publisher Information: |
Oxford Univ Press |
| Publication Year: |
2014 |
| Collection: |
Universidade Federal de São Paulo (UNIFESP): Repositório Institucional |
| Subject Terms: |
schizophrenia; gene-environment interaction; psychosis; epidemiology; genetics |
| Description: |
Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G x E), however, so far, thorough replication of findings is rare and G x E research still faces several conceptual and methodological challenges. in this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G x E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G x E in schizophrenia. While such investigations are now well underway, new challenges emerge for G x E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype. ; European Community ; Maastricht Univ, Med Ctr, Dept Psychiat & Neuropsychol, Sch Mental Hlth & Neurosci,South Limburg Mental H, NL-6200 MD Maastricht, Netherlands ; Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London WC2R 2LS, England ; Mondriaan Mental Hlth Trust, Maastricht, Heerlen, Netherlands ; Univ Groningen, Univ Med Ctr Groningen, Rob Giel Clin Res, Univ Ctr Psychiat, Groningen, Netherlands ; Kings Coll London, Inst Psychiat, Dept Hlth Serv & Populat Res, London WC2R 2LS, England ; Kings Coll London, Inst Psychiat, Dept Psychol, London WC2R 2LS, England ; Cardiff Univ, MRC, Ctr Neuropsychiat Genet, Cardiff CF10 3AX, S Glam, Wales ; Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany ; Dokuz Eylul Univ, Sch Med, Dept Psychiat, Konak, Turkey ; Istanbul Univ, Istanbul ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
729-736 |
| Language: |
English |
| ISSN: |
0586-7614 |
| Relation: |
Schizophrenia Bulletin; http://dx.doi.org/10.1093/schbul/sbu069; Schizophrenia Bulletin. Oxford: Oxford Univ Press, v. 40, n. 4, p. 729-736, 2014.; http://repositorio.unifesp.br/handle/11600/37894; WOS:000338130300004 |
| DOI: |
10.1093/schbul/sbu069 |
| Availability: |
http://repositorio.unifesp.br/handle/11600/37894; https://doi.org/10.1093/schbul/sbu069 |
| Rights: |
Acesso aberto ; http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html |
| Accession Number: |
edsbas.F7BA03C |
| Database: |
BASE |