| Title: |
A single-cell and spatial genomics atlas of human skin fibroblasts reveals shared disease-related fibroblast subtypes across tissues |
| Authors: |
Steele, L; Olabi, B; Roberts, K; Mazin, PV; Koplev, S; Tudor, C; Rumney, B; Admane, C; Jiang, T; Correa-Gallegos, D; Chakala, KP; Binkevich, A; Gopee, NH; Predeus, A; Prete, M; Winheim, E; Annusver, K; Forsthuber, A; Francis, L; Frech, S; Ganier, C; Layton, T; Liu, Y; Yuan, H; Gudjonsson, JE; Lichtenberger, BM; Mahil, S; Nanchahal, J; O'Toole, EA; Plikus, MV; Rinkevich, Y; Rognoni, E; Smith, CH; Teichmann, SA; Kasper, M; Foster, AR; Lotfollahi, M; Haniffa, M |
| Publisher Information: |
Nature Research |
| Publication Year: |
2025 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Fibroblasts sculpt the architecture and cellular microenvironments of various tissues. Here we constructed a spatially resolved atlas of human skin fibroblasts from healthy skin and 23 skin diseases, with comparison to 14 cross-tissue diseases. We define six major skin fibroblast subtypes in health and three that are disease-specific. We characterize two fibroblast subtypes further as they are conserved across tissues and are immune-related. The first, F3: fibroblastic reticular cell-like fibroblast (CCL19+CD74+HLA-DRA+), is a fibroblastic reticular cell-like subtype that is predicted to maintain the superficial perivascular immune niche. The second, F6: inflammatory myofibroblasts (IL11+MMP1+CXCL8+IL7R+), characterizes early human skin wounds, inflammatory diseases with scarring risk and cancer. F6: inflammatory myofibroblasts were predicted to recruit neutrophils, monocytes and B cells across multiple human tissues. Our study provides a harmonized nomenclature for skin fibroblasts in health and disease, contextualized with cross-tissue findings and clinical skin disease profiles. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1038/s41590-025-02267-8 |
| Availability: |
https://doi.org/10.1038/s41590-025-02267-8; https://ora.ox.ac.uk/objects/uuid:e84042a2-aa15-4e92-bbd8-f279575293b6 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.F7FD0E47 |
| Database: |
BASE |