| Title: |
Lack of effect of lowering LDL cholesterol on cancer: Meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy |
| Authors: |
Emberson, JR; Kearney, PM; Blackwell, L; Newman, C; Reith, C; Bhala, N; Holland, L; Peto, R; Keech, A; Collins, R; Simes, J; Baigent, C; De Lemos, J; Braunwald, E; Blazing, M; Murphy, S; Downs, JR; Gotto, A; Clearfield, M; Holdaas, H; Gordon, D; Davis, B; Koren, M; Dahlof, B; Poulter, N; Sever, P; Knopp, RH; Fellström, B; Jardine, A; Schmieder, R; Zannad, F; Goldbourt, U; Kaplinsky, E; Colhoun, HM; Betteridge, DJ; Durrington, PN; Hitman, GA; Fuller, J; Neil, A; Wanner, C; Krane, V; Sacks, F; Moyé, L; Pfeffer, M; Hawkins, CM; Kjekshus, J; Wedel, H; Wikstrand, J; Tavazzi, L; Maggioni, A; Marchioli, R; Tognoni, G; Franzosi, MG; Armitage, J; Parish, S; Sleight, P; Pedersen, TR; Ridker, PM; MacMahon, S; Marschner, I; Tonkin, A; Shaw, J; Serruys, PW; Nakamura, H; Knatterud, G; Furberg, C; Byington, R; Macfarlane, P; Cobbe, S; Ford, I; Murphy, M; Blauw, GJ; Packard, C; Shepherd, J; Wilhelmsen, L; Cannon, C; Bowman, L; La Rosa, J; Flather, M; Kastelein, J; Shear, C; Tobert, J; Varigos, J; White, H; Yusuf, S; Baxter, A; Barnes, EH; Buck, G; Herrington, WG; Kirby, A; Lewis, DA; Mellies, M; McGovern, M; Barclay, J; Belder, R; Mitchell, Y; Musliner, T; Ansquer, JC; Llewellyn, M; Bortolini, M; Barter, Philip |
| Contributors: |
Kronenberg, Florian |
| Source: |
urn:ISSN:1932-6203 ; PLoS ONE, 7, 1 |
| Publisher Information: |
Public Library of Science. |
| Publication Year: |
2012 |
| Collection: |
UNSW Sydney (The University of New South Wales): UNSWorks |
| Subject Terms: |
32 Biomedical and Clinical Sciences; 42 Health Sciences; 3211 Oncology and Carcinogenesis; Cancer; Clinical Research; Clinical Trials and Supportive Activities; Prevention; 6.1 Pharmaceuticals; 3 Good Health and Well Being; Anticholesteremic Agents; Cholesterol; LDL; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neoplasms; Randomized Controlled Trials as Topic; Cholesterol Treatment Trialists' (CTT) Collaboration; anzsrc-for: 32 Biomedical and Clinical Sciences; anzsrc-for: 42 Health Sciences; anzsrc-for: 3211 Oncology and Carcinogenesis |
| Description: |
© 2012 CTT Collaboration. Background: Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL cholesterol (LDL-C) with a statin using individual patient records from 175,000 patients in 27 large-scale statin trials. Methods and Findings: Individual records of 134,537 participants in 22 randomised trials of statin versus control (median duration 4.8 years) and 39,612 participants in 5 trials of more intensive versus less intensive statin therapy (median duration 5.1 years) were obtained. Reducing LDL-C with a statin for about 5 years had no effect on newly diagnosed cancer or on death from such cancers in either the trials of statin versus control (cancer incidence: 3755 [1.4% per year [py]] versus 3738 [1.4% py], RR 1.00 [95% CI 0.96-1.05]; cancer mortality: 1365 [0.5% py] versus 1358 [0.5% py], RR 1.00 [95% CI 0.93-1.08]) or in the trials of more versus less statin (cancer incidence: 1466 [1.6% py] vs 1472 [1.6% py], RR 1.00 [95% CI 0.93-1.07]; cancer mortality: 447 [0.5% py] versus 481 [0.5% py], RR 0.93 [95% CI 0.82-1.06]). Moreover, there was no evidence of any effect of reducing LDL-C with statin therapy on cancer incidence or mortality at any of 23 individual categories of sites, with increasing years of treatment, for any individual statin, or in any given subgroup. In particular, among individuals with low baseline LDL-C ( |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://hdl.handle.net/1959.4/unsworks_67269; https://doi.org/10.1371/journal.pone.0029849 |
| DOI: |
10.1371/journal.pone.0029849 |
| Availability: |
https://hdl.handle.net/1959.4/unsworks_67269; https://unsworks.unsw.edu.au/bitstreams/e707d02b-e8aa-4e7e-895e-b348df691074/download; https://doi.org/10.1371/journal.pone.0029849 |
| Rights: |
open access ; https://purl.org/coar/access_right/c_abf2 ; CC BY ; https://creativecommons.org/licenses/by/4.0/ ; free_to_read |
| Accession Number: |
edsbas.F81D6949 |
| Database: |
BASE |